Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy
文献类型：期刊论文
| 作者 | Hu, Haiyan2; Wang, Jing2; Wang, Hong1,3; Tang, Tao1,3; Li, Jie1,3; Wang, Zhiwan1,3; Sun, Kaoxiang2; Li, Yaping1,2,3 ; Zhang, Zhiwen1,3
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| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:13页码:3597-3610 |
| ISSN号 | 1838-7640 |
| 关键词 | lymph metastasis cell-penetrating peptide nanovehicle micelles deep penetration |
| DOI | 10.7150/thno.25608 |
| 文献子类 | Article |
| 英文摘要 | Lymph metastasis is a vital pathway of cancer cell dissemination, and insidious lymph node metastasis increases the risk of distant cancer metastasis. Current therapies for lymph metastasis are largely restricted by limited targeting and penetration capacity. Herein, we report that an r9 cell-penetrating peptide-based cabazitaxel nanovehicle (r9-CN) displays prominent lymph metastasis targeting and deep penetration ability after intravenous injection for effective anti-metastasis therapy. Methods: The r9-CN and CN nanovehicles were prepared by thin film dispersion, using DSPE-PEG2000 as the nano-carrier material and cabazitaxel as the model drug to fabricate r9-modified nano-micelles by self-assembly. The morphology, size, and stability in physiological solutions of r9-CN and CN were characterized. The targeting, biodistribution, deep penetration, and therapeutic efficacy of r9-CN and CN were systematically explored in vitro and in vivo. Results: The r9-CN nanovehicle consists of homogeneous particles with a mean diameter of 13 nm and zeta potential of +0.75 mV. Compared with the nanovehicle lacking the r9 peptide (CN), r9-CN exhibits long retention and deep penetration in the tumor mass, and considerably enhances accumulation and flexible permeation in metastatic lymph nodes, thereby notably suppressing primary tumor growth, lymph node metastasis, and distant lung metastasis. Conclusion: The cumulative findings reveal that r9-CN offers a promising delivery platform, enabling efficient lymph metastasis targeting and deep penetration for effective anti-metastasis therapy. |
| WOS关键词 | GUIDED PHOTOTHERMAL THERAPY ; INHIBIT CANCER METASTASIS ; NODE METASTASIS ; BREAST-CANCER ; DRUG-DELIVERY ; TUMOR-TISSUE ; LUNG-CANCER ; NEOADJUVANT CHEMOTHERAPY ; EXTRACELLULAR-MATRIX ; POLYMERIC MICELLES |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| 出版者 | IVYSPRING INT PUBL |
| WOS记录号 | WOS:000435485300012 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272310]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Sun, Kaoxiang; Li, Yaping; Zhang, Zhiwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ,Collaborat Innovat Ctr Adv Drug Deliv, Yantai 264005, Shandong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Haiyan,Wang, Jing,Wang, Hong,et al. Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy[J]. THERANOSTICS,2018,8(13):3597-3610. |
| APA | Hu, Haiyan.,Wang, Jing.,Wang, Hong.,Tang, Tao.,Li, Jie.,...&Zhang, Zhiwen.(2018).Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy.THERANOSTICS,8(13),3597-3610. |
| MLA | Hu, Haiyan,et al."Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy".THERANOSTICS 8.13(2018):3597-3610. |
入库方式： OAI收割
来源：上海药物研究所
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