Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV Infection
文献类型：期刊论文
| 作者 | Yang, Li1; Lu, Mengji2 |
| 刊名 | CURRENT MEDICINAL CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 25期号:7页码:802-813 |
| 关键词 | Hepatitis B virus core protein capsid assembly capsid assembly modulator misassembly antiviral therapy |
| ISSN号 | 0929-8673 |
| DOI | 10.2174/0929867324666170704121800 |
| 文献子类 | Review |
| 英文摘要 | Hepatitis B virus (HBV) infection is still a major health problem worldwide. The current available antiviral drugs for the treatment of chronic HBV infection do not achieve satisfactory results. Thus, it is desirable to develop novel anti-HBV drugs based on the recent advances of basic research on molecular biology of HBV. HBV nucleocapsid assembly is now considered as a potential target of anti-HBV therapy. Structural and functional analysis provided essential insight of molecular interaction of the components of HBV nucleocapsid. Prototypes of small molecule modulators of HBV nucleocapsid assembly were developed and partly tested in clinical phase I. In the present review, the recent advances in HBV molecular biology and approach to develop inhibitors for anti-HBV treatment based on the disruption of viral nucleocapsids by either prevention of assembly or induction of misassembly will be summarized. We will discuss the future concepts of anti-HBV treatment based on such new approaches. |
| WOS关键词 | PROTEIN-PROTEIN INTERACTIONS ; FREE CAPSID FORMATION ; CORE PROTEIN ; LIFE-CYCLE ; PRECLINICAL CHARACTERIZATION ; IN-VITRO ; REPLICATION ; DERIVATIVES ; COMPOUND ; ANALOGS |
| 资助项目 | Deutsche Forschungsgemeischaft[TRR60] ; Institutes for Drug Discovery and Development[00000000] ; Chinese Academy of Sciences[CASIMM0120162013] ; National Nature Science Foundation of China (NSFC)[31570166] ; Natural Science Foundation of Shanghai[17ZR1436400] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000427719500003 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272327]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lu, Mengji |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Lab Immunopharmacol, Shanghai, Peoples R China; 2.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany |
| 推荐引用方式 GB/T 7714 | Yang, Li,Lu, Mengji. Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV Infection[J]. CURRENT MEDICINAL CHEMISTRY,2018,25(7):802-813. |
| APA | Yang, Li,&Lu, Mengji.(2018).Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV Infection.CURRENT MEDICINAL CHEMISTRY,25(7),802-813. |
| MLA | Yang, Li,et al."Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV Infection".CURRENT MEDICINAL CHEMISTRY 25.7(2018):802-813. |
入库方式： OAI收割
来源：上海药物研究所
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