IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice
文献类型：期刊论文
| 作者 | He, Bin2; Hu, Hai-yan2; Tan, Tao1,3; Wang, Hong1,3; Sun, Kao-xiang2; Li, Ya-ping1,3 ; Zhang, Zhi-wen1,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2018-01 |
| 卷号 | 39期号:1页码:132-139 |
| 关键词 | cancer metastasis lymphatic metastasis IR-780 polymeric micelles photothermal therapy |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.109 |
| 文献子类 | Article |
| 英文摘要 | Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PTT applications in treatment of metastatic breast cancer. |
| WOS关键词 | TUMOR-METASTASIS ; LUNG METASTASIS ; PANCREATIC-CANCER ; CARBON NANOTUBES ; DRUG-CARRIER ; NANOPARTICLES ; INHIBITION ; GROWTH ; SIZE ; NANOTHERAPEUTICS |
| 资助项目 | National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[81521005] ; Institutes for Drug Discovery and Development of CAS[CASIMM0120163005] ; Youth Innovation Promotion Association of CAS[00000000] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6159149 |
| WOS记录号 | WOS:000423867300013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272338]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Sun, Kao-xiang; Zhang, Zhi-wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Bin,Hu, Hai-yan,Tan, Tao,et al. IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice[J]. ACTA PHARMACOLOGICA SINICA,2018,39(1):132-139. |
| APA | He, Bin.,Hu, Hai-yan.,Tan, Tao.,Wang, Hong.,Sun, Kao-xiang.,...&Zhang, Zhi-wen.(2018).IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice.ACTA PHARMACOLOGICA SINICA,39(1),132-139. |
| MLA | He, Bin,et al."IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice".ACTA PHARMACOLOGICA SINICA 39.1(2018):132-139. |
入库方式： OAI收割
来源：上海药物研究所
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