Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
文献类型：期刊论文
| 作者 | Zhou, Lei1,2,3; Wang, Hao3; Li, Yaping1,2
|
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:4页码:1059-1074 |
| 关键词 | multidrug resistance cancer tumor microenvironment stimuli-responsive nanomedicines chemotherapy |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.22679 |
| 文献子类 | Review |
| 英文摘要 | Chemotherapy is still a main option for cancer therapy, but its efficacy is often unsatisfying due to multidrug resistance (MDR). The tumor microenvironment is considered a dominant factor causing MDR. Stimuli-responsive nanomedicines exhibit many superiorities for reversal of MDR. As smart systems, stimuli-responsive nanomedicines are desirable for achieving site-specific accumulation and triggered drug release in response to slight changes in physicochemical properties in pathological conditions or to exogenous stimuli. In this review, we highlight the current progress of various nanomedicines with different stimuli-responsive capabilities for overcoming MDR. The materials, design, construction as well as efficacy in overcoming MDR of these nanomedicines are discussed. Eventually, we look forward to forthcoming intelligent nanoparticle systems with new mechanisms to deliver drugs for practical applications in conquering cancer MDR. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; ANTICANCER DRUG-DELIVERY ; P-GLYCOPROTEIN INHIBITOR ; WALLED CARBON NANOTUBES ; THERAPY IN-VITRO ; BREAST-CANCER ; CO-DELIVERY ; PHOTODYNAMIC THERAPY ; HYALURONIC-ACID ; TUMOR MICROENVIRONMENT |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81690265] ; Key scientific research program of CAS[QYZDJ-SSW-SMC020] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000419234800013 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272348]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lei,Wang, Hao,Li, Yaping. Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance[J]. THERANOSTICS,2018,8(4):1059-1074. |
| APA | Zhou, Lei,Wang, Hao,&Li, Yaping.(2018).Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance.THERANOSTICS,8(4),1059-1074. |
| MLA | Zhou, Lei,et al."Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance".THERANOSTICS 8.4(2018):1059-1074. |
入库方式： OAI收割
来源：上海药物研究所
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