Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer
文献类型：期刊论文
| 作者 | Zhou, Fangyuan1,3,4; Feng, Bing1,4,5; Wang, Tingting1,4,5; Wang, Dangge1,4,5; Cui, Zhirui1,4; Wang, Siling3; Ding, Chunyong1,4,5 ; Zhang, Zhiwen1,4,5; Liu, Jian2; Yu, Haijun1,4,5
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2017-12-08 |
| 卷号 | 27期号:46 |
| 关键词 | cancer theranostics local-regional therapy prodrug vesicles reactive oxygen species triple-negative breast cancer |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201703674 |
| 文献子类 | Article |
| 英文摘要 | A reactive oxygen species (ROS)-activatable doxorubicin (Dox) prodrug vesicle (RADV) is presented for image-guided ultrafast drug release and local-regional therapy of the metastatic triple-negative breast cancer (TNBC). RADV is prepared by integrating a ROS-activatable Dox prodrug, a poly(ethylene glycol) (PEG)-modified photosensitizer pyropheophorbide-a, an unsaturated phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine, and cholesterol into one single nanoplatform. RADV is of extremely high drug loading ratio (27.5 wt%) by self-assembly of the phospholipid-mimic Dox prodrug into the liposomal bilayer membrane. RADV displays good colloidal stability to prevent premature drug leakage during the blood circulation and inert photochemotoxicity to avoid nonspecific side effect. RADV passively accumulates at tumor site through the enhanced permeability and retention effect when administrated systemically. Once deposited at the tumor site, RADV generates fluorescent and photoacoustic signals to guide near-infrared (NIR) laser irradiation, which can induce localized ROS generation, not only to trigger prodrug activation and ultrafast drug release but also conduct photodynamic therapy in a spatiotemporally controlled manner. In combination with NIR laser irradiation, RADV efficiently inhibits the tumor growth and distant metastasis of TNBC. Local-regional tumor therapy using intelligent theranostic nanomedicine might provide an alternative option for highly efficient treatment of the metastatic TNBC. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; TUMOR ACCUMULATION ; ANTICANCER DRUG ; NANOPARTICLES ; CHEMOTHERAPY ; DELIVERY ; NANOMEDICINE ; PENETRATION ; IMMUNOTHERAPY ; STRATEGIES |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; Youth Innovation Promotion Association CAS[2014218] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000417187200011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272356]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Siling; Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Fangyuan,Feng, Bing,Wang, Tingting,et al. Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(46). |
| APA | Zhou, Fangyuan.,Feng, Bing.,Wang, Tingting.,Wang, Dangge.,Cui, Zhirui.,...&Li, Yaping.(2017).Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,27(46). |
| MLA | Zhou, Fangyuan,et al."Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 27.46(2017). |
入库方式： OAI收割
来源：上海药物研究所
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