Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis
文献类型：期刊论文
| 作者 | Fan, Yao-Yue2; Xu, Jin-Biao2; Liu, Hong-Chun2 ; Gan, Li-She1; Ding, Jian2; Yue, Jian-Min2
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2017-12 |
| 卷号 | 80期号:12页码:3160-3167 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.7b00412 |
| 文献子类 | Article |
| 英文摘要 | Ten new cephalotane-type diterpenoids, cephanolides A-J (1-10), and two known analogues were isolated and characterized from Cephalotaxus sinensis. Compounds 1-3 represent the first examples of A-ring-contracted cephalotane-type dinorditerpenoids, and compound 4 is an A-ring-contracted norditerpenoid. The biosynthetic pathways for compounds 1-4 are postulated with the coexisting cephalotane-type troponoids as the precursors. Compounds 11 and 12 showed significant cytotoxicities against a panel of tumor cell lines (A549, KB, HL-60, and HT-29) with IC50 values ranging from 0.464 to 6.093 mu M. |
| WOS关键词 | NATURAL-PRODUCTS ; FORTUNEI ; ASSAY |
| 资助项目 | National Natural Science Foundation of P. R China[21532007] ; National Natural Science Foundation of P. R China[U1302222] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development"[00000000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020321] ; Chinese Academy of Sciences[CASIMM0120153009] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000418879300010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272361]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fan, Yao-Yue,Xu, Jin-Biao,Liu, Hong-Chun,et al. Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(12):3160-3167. |
| APA | Fan, Yao-Yue,Xu, Jin-Biao,Liu, Hong-Chun,Gan, Li-She,Ding, Jian,&Yue, Jian-Min.(2017).Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis.JOURNAL OF NATURAL PRODUCTS,80(12),3160-3167. |
| MLA | Fan, Yao-Yue,et al."Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis".JOURNAL OF NATURAL PRODUCTS 80.12(2017):3160-3167. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。