Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer
文献类型：期刊论文
| 作者 | Dong, Xin-yue3; Lang, Tian-qun1,2; Yin, Qi1,2 ; Zhang, Peng-cheng1,2; Li, Ya-ping1,2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2017-12 |
| 卷号 | 38期号:12页码:1655-1662 |
| 关键词 | pH-sensitive polymer co-delivery micelle docetaxel silibinin breast cancer mouse breast cancer cell line 4T1 metastasis |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.74 |
| 文献子类 | Article |
| 英文摘要 | Breast cancer is the most vicious killer for women, and tumor metastasis is one of the leading causes of breast cancer therapy failure. In this study, a new pH-sensitive polymer (polyethylene glycol-block-poly[(1,4-butanediol)-diacrylate-beta-N, N-diisopropylethylenediamine], BDP) was synthesized. Based on BDP, docetaxel/ silibinin co-delivery micelles (DSMs) was constructed. DSM had a well-defined spherical shape under the transmission electron microscope with average hydrodynamic diameter of 85.3 +/- 0.4 nm, and were stable in the bloodstream but could dissociate to release the chemotherapeutic agents in the low pH environment of the endo/ lysosomes in the tumor cells. Compared with free drugs, DSM displayed greatly enhanced cellular uptake, higher cytotoxicity and a stronger antimetastasis effect against mouse breast cancer cell line 4T1. In 4T1 tumor-bearing mice treated with DSM (twice a week for 3 weeks), the inhibition rate on tumor growth and metastasis reached 71.9% and 80.1%, respectively. These results reveal that DSM might be a promising drug delivery system for metastatic breast cancer therapy. |
| WOS关键词 | ANTICANCER EFFICACY ; POLYMERIC MICELLES ; TUMOR-METASTASIS ; CELLULAR UPTAKE ; LUNG-CANCER ; IN-VITRO ; CELLS ; NANOPARTICLES ; DOXORUBICIN ; NANOCARRIERS |
| 资助项目 | National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81230029] ; Youth Innovation Promotion Association of CAS[2015226] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6136214 |
| WOS记录号 | WOS:000416938000007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272369]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yin, Qi; Li, Ya-ping |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Dong, Xin-yue,Lang, Tian-qun,Yin, Qi,et al. Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer[J]. ACTA PHARMACOLOGICA SINICA,2017,38(12):1655-1662. |
| APA | Dong, Xin-yue,Lang, Tian-qun,Yin, Qi,Zhang, Peng-cheng,&Li, Ya-ping.(2017).Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer.ACTA PHARMACOLOGICA SINICA,38(12),1655-1662. |
| MLA | Dong, Xin-yue,et al."Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer".ACTA PHARMACOLOGICA SINICA 38.12(2017):1655-1662. |
入库方式： OAI收割
来源：上海药物研究所
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