Ancient hybridization and strong adaptation to viruses across African vervet monkey populations
文献类型：期刊论文
| 作者 | Svardal, Hannes3,18; Jasinska, Anna J.1,17; Apetrei, Cristian15,16; Coppola, Giovanni14,17; Huang, Yu13; Schmitt, Christopher A.12; Jacquelin, Beatrice11; Ramensky, Vasily10,17; Mueller-Trutwin, Michaela11; Antonio, Martin9 |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2017-12 |
| 卷号 | 49期号:12页码:1705-+ |
| ISSN号 | 1061-4036 |
| DOI | 10.1038/ng.3980 |
| 文献子类 | Article |
| 英文摘要 | Vervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV. |
| WOS关键词 | SIMIAN IMMUNODEFICIENCY VIRUS ; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY ; GENETIC-VARIATION ; SIV INFECTION ; SOOTY MANGABEYS ; RHESUS MACAQUES ; HUMAN BRAIN ; HISTORY ; GENOMES ; DNA |
| 资助项目 | US National Institutes of Health[R01RR016300] ; US National Institutes of Health[R01OD010980] ; Austrian Ministry of Science and Research[00000000] ; National Institute of Allergy and Infectious Diseases (NIAID)[RO1 AI119346] ; National Institute of Neurological Disorders and Stroke (NINDS) Informatics Center for Neurogenetics and Neurogenomics[P30 NS062691] ; [R24OD010976] |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000416480600009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272377]  |
| 专题 | 生物技术药物研发中心（筹） 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 药物安全性评价中心 |
| 通讯作者 | Nordborg, Magnus |
| 作者单位 | 1.Polish Acad Sci, Inst Bioorgan Chem, Poznan, Poland; 2.Nationwide Childrens Hosp, Inst Genom Med, Columbus, OH USA 3.Univ Cambridge, Dept Genet, Cambridge, England; 4.Washington Univ St Louis, McDonnell Genome Inst, St Louis, MO USA; 5.Univ Wisconsin Milwaukee, Dept Anthropol, Milwaukee, WI USA; 6.McGill Univ, Dept Human Genet, Montreal, PQ, Canada; 7.Univ Free State, Dept Genet, Bloemfontein, South Africa; 8.Jackson Lab Genom Med, Farmington, CT USA; 9.MRC, Gambia Unit, Fajara, Gambia; 10.Moscow Inst Phys & Tech, Dolgoprudnyi, Russia; |
| 推荐引用方式 GB/T 7714 | Svardal, Hannes,Jasinska, Anna J.,Apetrei, Cristian,et al. Ancient hybridization and strong adaptation to viruses across African vervet monkey populations[J]. NATURE GENETICS,2017,49(12):1705-+. |
| APA | Svardal, Hannes.,Jasinska, Anna J..,Apetrei, Cristian.,Coppola, Giovanni.,Huang, Yu.,...&Nordborg, Magnus.(2017).Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.NATURE GENETICS,49(12),1705-+. |
| MLA | Svardal, Hannes,et al."Ancient hybridization and strong adaptation to viruses across African vervet monkey populations".NATURE GENETICS 49.12(2017):1705-+. |
入库方式： OAI收割
来源：上海药物研究所
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