Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate
文献类型：期刊论文
| 作者 | Jasinska, Anna J.3,4; Zelaya, Ivette5; Service, Susan K.3; Peterson, Christine B.6; Cantor, Rita M.3,7; Choi, Oi-Wa3; DeYoung, Joseph3; Eskin, Eleazar7,8; Fairbanks, Lynn A.3; Fears, Scott3 |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2017-12 |
| 卷号 | 49期号:12页码:1714-+ |
| ISSN号 | 1061-4036 |
| DOI | 10.1038/ng.3959 |
| 文献子类 | Article |
| 英文摘要 | By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex-and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders. |
| WOS关键词 | CHLOROCEBUS-AETHIOPS-SABAEUS ; GENOME-WIDE ASSOCIATION ; MARIE-TOOTH DISEASE ; VERVET MONKEY ; HUMAN BRAIN ; LINKAGE ANALYSIS ; TRAITS ; EVOLUTION ; TRANSCRIPTOME ; RNA |
| 资助项目 | US National Institutes of Health[U54HG00307907] ; US National Institutes of Health[P40RR019963/OD010965] ; US National Institutes of Health[R01RR016300/OD010980] ; US National Institutes of Health[R37MH060233] ; US National Institutes of Health[UL1DE019580] ; US National Institutes of Health[PL1NS062410] ; Wellcome Trust[00000000] ; Wellcome Trust[WT108749/Z/15/Z] ; European Molecular Biology Laboratory[00000000] ; EMBO[aALTF1672-2014] ; Takeda Pharmaceuticals Company[00000000] ; F. Hoffman-La Roche[00000000] ; [RL1MH083270] ; [P30NS062691] ; [R01MH101782] ; [T32MH073526] ; [R01MH085542] ; [R01MH093725] ; [P50MH066392] ; [P50MH080405] ; [R01MH097276] ; [RO1MH-075916] ; [P50M096891] ; [P50MH084053S1] ; [R37MH057881] ; [R37MH057881S1] ; [HHSN271201300031C] ; [AG02219] ; [AG05138] ; [MH06692] |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000416480600010 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272378]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Freimer, Nelson B. |
| 作者单位 | 1.Binghamton Univ, Dept Psychol, Binghamton, NY USA 2.Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90024 USA; 3.Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet,Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA; 4.Polish Acad Sci, Inst Bioorgan Chem, Poznan, Poland; 5.Univ Calif Los Angeles, Interdept Program Bioinformat, Los Angeles, CA USA; 6.Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA; 7.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA; 8.Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90024 USA; 9.Univ Calif Los Angeles, Interdept Grad Program Neurosci, Los Angeles, CA USA; 10.Wellcome Trust Sanger Inst, Hinxton, England; |
| 推荐引用方式 GB/T 7714 | Jasinska, Anna J.,Zelaya, Ivette,Service, Susan K.,et al. Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate[J]. NATURE GENETICS,2017,49(12):1714-+. |
| APA | Jasinska, Anna J..,Zelaya, Ivette.,Service, Susan K..,Peterson, Christine B..,Cantor, Rita M..,...&Freimer, Nelson B..(2017).Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.NATURE GENETICS,49(12),1714-+. |
| MLA | Jasinska, Anna J.,et al."Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate".NATURE GENETICS 49.12(2017):1714-+. |
入库方式： OAI收割
来源：上海药物研究所
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