Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance
文献类型：期刊论文
| 作者 | Meng, Qingshuo1,2,4; Meng, Jia1,2,4; Ran, Wei1,2,4; Su, Jinghan1,2,4; Yang, Yuguang3; Zhang, Pengcheng1,2,4 ; Li, Yaping1,2,4
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| 刊名 | CHEMICAL COMMUNICATIONS
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| 出版日期 | 2017-11-28 |
| 卷号 | 53期号:92页码:12438-12441 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c7cc07465d |
| 文献子类 | Article |
| 英文摘要 | We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against several cancer cell lines. Experimental and simulation results reveal that the annihilation abates with increasing distance between the PS and drugs via confining the PS and drugs into separated vehicles. As a result, antagonism can be switched to synergism in treating both drug sensitive and resistant cancer cells. |
| WOS关键词 | TRIGGERED DRUG-RELEASE ; SINGLET OXYGEN ; COMBINATION THERAPY ; RESISTANT TUMOR ; CANCER ; NANOPARTICLES ; LIPOSOMES ; CELL ; CONVERSION ; CISPLATIN |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81671808] ; Youth Innovation Promotion Association of CAS[2017335] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000415661300013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272392]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Pengcheng; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 North Charles St, Baltimore, MD 21218 USA 4.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Meng, Qingshuo,Meng, Jia,Ran, Wei,et al. Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance[J]. CHEMICAL COMMUNICATIONS,2017,53(92):12438-12441. |
| APA | Meng, Qingshuo.,Meng, Jia.,Ran, Wei.,Su, Jinghan.,Yang, Yuguang.,...&Li, Yaping.(2017).Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance.CHEMICAL COMMUNICATIONS,53(92),12438-12441. |
| MLA | Meng, Qingshuo,et al."Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance".CHEMICAL COMMUNICATIONS 53.92(2017):12438-12441. |
入库方式： OAI收割
来源：上海药物研究所
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