Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium
文献类型：期刊论文
| 作者 | Du, Qizhen2,3; Zhao, Yongchun3,4,5; Liu, Hongchun1 ; Tang, Chunping4,5; Zhang, Minmin1; Ke, Changqiang4,5; Ye, Yang4,5,6
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2017-11 |
| 卷号 | 83期号:17页码:1361-1367 |
| 关键词 | Croton tiglium Euphorbiaceae phorbol esters isolation structure elucidation cytotoxicity |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0043-110227 |
| 文献子类 | Article |
| 英文摘要 | Nine new and eleven known phorbol esters were isolated from an acetone extract of the seeds of Croton tiglium. Their structures were determined by extensive analysis of spectroscopic data. Eleven of these compounds were evaluated for their inhibition activity on human tumor cell lines HL-60 and lung carcinoma A549. 12-O-Tiglylphorbol-13-acetate (11), 12-O-(2-methyl)-butyrylphorbol-13-aetate (12), and 12-O-tiglylphorbol-13-isobutyrate (13) exhibited strong inhibition activity against both HL-60 and A549 cell lines with IC50 values <= 0.02 and <= 0.1 mu g/mL, respectively. Compound 18 showed strong inhibition activity against the HL-60 cell line with an IC50 value of 0.02 mu g/mL. |
| WOS关键词 | DITERPENOIDS ; EXTRACTS ; OIL ; L. |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds[81473112] ; National Natural Science Funds[81573305] ; National Natural Science Funds[81673327] ; Bureau of Science & Technology for Development, Chinese Academy of Sciences[ZSTH-009] ; Bureau of Science & Technology for Development, Chinese Academy of Sciences[ZSTH-014] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000415715200007 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272419]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai, Peoples R China; 2.Zhejiang A&F Univ, Key Lab Qual Improvement Agr Prod Zhejiang Prov, Coll Agr & Food Sci, Linan, Peoples R China; 3.Zhejiang Gongshang Univ, Inst Food Chem, Hangzhou, Zhejiang, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Qizhen,Zhao, Yongchun,Liu, Hongchun,et al. Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium[J]. PLANTA MEDICA,2017,83(17):1361-1367. |
| APA | Du, Qizhen.,Zhao, Yongchun.,Liu, Hongchun.,Tang, Chunping.,Zhang, Minmin.,...&Ye, Yang.(2017).Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium.PLANTA MEDICA,83(17),1361-1367. |
| MLA | Du, Qizhen,et al."Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium".PLANTA MEDICA 83.17(2017):1361-1367. |
入库方式： OAI收割
来源：上海药物研究所
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