Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer
文献类型：期刊论文
| 作者 | Hu, Chunhua2,3,4; Liu, Xiaoyu2,3,4; Ran, Wei1,3,4; Meng, Jia1,3,4; Zhai, Yihui1,3,4; Zhang, Pengcheng1,3,4 ; Yin, Qi1,3,4; Yu, Haijun1,3,4; Zhang, Zhiwen1,3,4; Li, Yaping1,3,4
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2017-11 |
| 卷号 | 144页码:60-72 |
| 关键词 | Self-assembly Hydrogel Cancer associated fibroblasts Metastasis Triple negative breast cancer |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2017.08.009 |
| 文献子类 | Article |
| 英文摘要 | Preoperative chemotherapy is effective in improving the prognosis of patients, but its efficacy is impeded by cancer associated fibroblasts (CAFs) that enhance the survival, growth, and metastasis of cancer cells. To inhibit the activity of CAFs, prolonged and localized drug exposure is necessary. Here, we report on the rational design, screening, and evaluation of an injectable peptide hydrogel as a local losartan depot aiming to inhibit CAFs and potentiate chemotherapy. We synthesized a set of peptide derivatives and found that C-16-GNNQQNYKD-OH (C-16-N) surpassed the others in hydrogel formation and drug encapsulation, due to its flexible hydrocarbon tail and interpeptide hydrogen bonding that allowed supra molecular self-assembly into long filaments with hydrophobic cores. C-16-N co-assembled with losartan to form hydrogel from which losartan was sustainably released over 9 days. After intratumoral injection, the hydrogel could be retained in the tumor for more than 9 days, significantly inhibited the CAFs and collagen synthesis in orthotopic 4T1 tumors, and enhanced the efficacy of PEGylated doxorubicin-loaded liposomes (Dox-L) in inhibiting the tumor growth (64% vs. Dox-L alone) and lung metastasis (80% vs. Dox-L alone). These results provide important guiding principles for the rational design of injectable peptide hydrogels aiming to regulate CAFs and improve chemotherapy. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | AMPHIPHILE NANOFIBERS ; DRUG-DELIVERY ; TUMOR-STROMA ; PREOPERATIVE CHEMOTHERAPY ; SUPRAMOLECULAR HYDROGELS ; CONTROLLED-RELEASE ; RATIONAL DESIGN ; EFFICACY ; TISSUE ; PROGRESSION |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81671808] ; Shanghai Pujiang Program[15PJ1409900] ; Youth Innovation Promotion Association of CAS[2017335] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000411420000006 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272436]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Pengcheng; Li, Yaping |
| 作者单位 | 1.UCAS, Beijing 100049, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hu, Chunhua,Liu, Xiaoyu,Ran, Wei,et al. Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer[J]. BIOMATERIALS,2017,144:60-72. |
| APA | Hu, Chunhua.,Liu, Xiaoyu.,Ran, Wei.,Meng, Jia.,Zhai, Yihui.,...&Li, Yaping.(2017).Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer.BIOMATERIALS,144,60-72. |
| MLA | Hu, Chunhua,et al."Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer".BIOMATERIALS 144(2017):60-72. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。