Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts
文献类型：期刊论文
| 作者 | Wang, Dong-Yu1,2,3,4,5; Morimoto, Koki2; Yang, Ze-Kun2,3,4; Wang, Chao2,3,4; Uchiyama, Masanobu2,3,4 |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2017-10-05 |
| 卷号 | 12期号:19页码:2554-2557 |
| 关键词 | chemoselectivity C-N bond cleavage cross-coupling organozinc single electron transfer |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201701132 |
| 文献子类 | Article |
| 英文摘要 | We report a direct cross-coupling reaction between diarylzinc (Ar2Zn) and aryltrimethylammonium salts (ArNMe3+center dot-OTf) in the presence of LiCl, via C-N bond cleavage. The reaction takes place smoothly upon heating in THF without any external catalyst, enabling an efficient and chemoselective formation of biaryl products. Mechanistic studies indicate that the reaction proceeds through a single electron transfer route. |
| WOS关键词 | SINGLE-ELECTRON-TRANSFER ; CROSS-COUPLING REACTIONS ; ARYL GRIGNARD-REAGENTS ; ARYLTRIMETHYLAMMONIUM IODIDES ; NICKEL-COMPLEXES ; ALKENYL HALIDES ; ZINC REAGENTS ; BORYLATION ; ARYLSTANNANES ; ACTIVATION |
| 资助项目 | JSPS[17H05430] ; JSPS KAKENHI[17H06173] ; Asahi Glass Foundation[00000000] ; Nagase Science Technology Development Foundation[00000000] ; Sumitomo Foundation[00000000] ; Kobayashi International Scholarship Foundation[00000000] ; YakuGaku ShinKoKai Foundation[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000412325700011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272456]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Wang, Chao; Uchiyama, Masanobu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo To 1130033, Japan; 3.RIKEN, Adv Elements Chem Res Team, RIKEN Ctr Sustainable Resource Sci, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; 4.RIKEN, Elements Chem Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Dong-Yu,Morimoto, Koki,Yang, Ze-Kun,et al. Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts[J]. CHEMISTRY-AN ASIAN JOURNAL,2017,12(19):2554-2557. |
| APA | Wang, Dong-Yu,Morimoto, Koki,Yang, Ze-Kun,Wang, Chao,&Uchiyama, Masanobu.(2017).Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts.CHEMISTRY-AN ASIAN JOURNAL,12(19),2554-2557. |
| MLA | Wang, Dong-Yu,et al."Organozinc-Mediated Direct C-C Bond Formation via C-N Bond Cleavage of Ammonium Salts".CHEMISTRY-AN ASIAN JOURNAL 12.19(2017):2554-2557. |
入库方式： OAI收割
来源：上海药物研究所
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