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Asymmetric Synthesis of Chiral Trifluoromethyl Containing Heterocyclic Amino Acids

文献类型：期刊论文

作者Zhao, Liang1,2,3; Zhou, Shengbin1,3; Tong, Junhua1,2,3; Wang, Jiang1,3; Liu, Hong1,3
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2017-10
卷号35期号:10页码:1540-1548
关键词trifluoromethyl containing heterocyclic amino acids Ni(II)-complex of glycine asymmetric Michael addition alpha,beta-unsaturated ketones
ISSN号1001-604X
DOI10.1002/cjoc.201700257
文献子类Article
英文摘要An operationally convenient, asymmetric synthesis of chiral trifluoromethyl containing heterocyclic amino acids has been developed via Michael addition reaction of chiral equivalent of Ni(II)-complex of glycine and beta-trifluoromethylated-alpha,beta-unsaturated ketones. The simplicity of the experimental procedures and high stereochemical outcome of the presented method render these heterocyclic amino acids readily available for systematic medicinal chemistry studies and de novo peptide design.
WOS关键词MEDICINAL CHEMISTRY ; ENANTIOSELECTIVE SYNTHESIS ; 1,3-DIPOLAR CYCLOADDITION ; PHOTOREDOX CATALYSIS ; AZOMETHINE YLIDES ; NI(II) COMPLEXES ; MICHAEL ADDITION ; SCHIFF-BASE ; GLYCINE ; FLUORINE
资助项目National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21472209] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB-910304] ; Shanghai Science and Technology Development Fund[15QA1404400] ; National SAMP[00000000] ; T Major Projects[2014ZX09507002-001] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040201] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040202]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:6104467
WOS记录号WOS:000413044400007
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/272464]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Wang, Jiang; Liu, Hong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Liang,Zhou, Shengbin,Tong, Junhua,et al. Asymmetric Synthesis of Chiral Trifluoromethyl Containing Heterocyclic Amino Acids[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(10):1540-1548.
APA Zhao, Liang,Zhou, Shengbin,Tong, Junhua,Wang, Jiang,&Liu, Hong.(2017).Asymmetric Synthesis of Chiral Trifluoromethyl Containing Heterocyclic Amino Acids.CHINESE JOURNAL OF CHEMISTRY,35(10),1540-1548.
MLA Zhao, Liang,et al."Asymmetric Synthesis of Chiral Trifluoromethyl Containing Heterocyclic Amino Acids".CHINESE JOURNAL OF CHEMISTRY 35.10(2017):1540-1548.

入库方式： OAI收割

来源：上海药物研究所

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