Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba
文献类型：期刊论文
| 作者 | Huang, Qing-Hua1; Lei, Chun1; Wang, Pei-Pei2 ; Li, Jing-Ya2; Li, Jia2; Hou, Ai-Jun1
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017-10 |
| 卷号 | 122页码:138-143 |
| 关键词 | Morus alba Moraceae Isoprenylated phenolics Albasins A-D Protein tyrosine phosphatase 1B |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2017.09.006 |
| 文献子类 | Article |
| 英文摘要 | Two new Diels-Alder adducts, albasins A and B (1 and 2), one new isoprenylated 2-arylbenzofuran, albasin C (3), one new isoprenylated flavone, albasin D (4), together with sixteen known phenolic compounds, were isolated from the root bark of Morus alba. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC50 values ranging from 0.57 to 7.49 mu M. |
| WOS关键词 | CULTIVATED MULBERRY TREE ; ALDER TYPE ADDUCTS ; TYROSINE-PHOSPHATASE 1B ; ROOT BARK ; 2-ARYLBENZOFURAN DERIVATIVES ; CALLUS-CULTURE ; LHOU KOIDZ ; CONSTITUENTS ; KUWANON ; FLAVONOIDS |
| 资助项目 | National Natural Science Foundation of China[21372049] ; National Natural Science Foundation of China[81222045] ; Shanghai Commission of Science and Technology[14431905400] ; National Key Research and Development Program of China[2016YFC1305500] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000413383500024 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272467]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Hou, Ai-Jun |
| 作者单位 | 1.Fudan Univ, Dept Phannacognosy, Sch Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Qing-Hua,Lei, Chun,Wang, Pei-Pei,et al. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba[J]. FITOTERAPIA,2017,122:138-143. |
| APA | Huang, Qing-Hua,Lei, Chun,Wang, Pei-Pei,Li, Jing-Ya,Li, Jia,&Hou, Ai-Jun.(2017).Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba.FITOTERAPIA,122,138-143. |
| MLA | Huang, Qing-Hua,et al."Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba".FITOTERAPIA 122(2017):138-143. |
入库方式： OAI收割
来源：上海药物研究所
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