Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors
文献类型：期刊论文
| 作者 | Wang, Tingting2,3,4; Wang, Dangge2,3,4; Liu, Jianping2,3; Feng, Bing2,3,4; Zhou, Fangyuan2,3; Zhang, Hanwu2,3; Zhou, Lei2,3; Yin, Qi2,3 ; Zhang, Zhiwen2,3; Cao, Zhonglian1
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2017-09 |
| 卷号 | 17期号:9页码:5429-5436 |
| 关键词 | Drug delivery barriers acid-responsive ligand presentation tumor microenvironment cancer therapy |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.7b02031 |
| 文献子类 | Article |
| 英文摘要 | The success of cancer chemotherapy is impeded by poor drug delivery efficiency due to the existence of a series of pathophysiological barriers in the tumor: In this study, we reported a tumor acidity-triggered ligand-presenting (ATLP) nanoparticle for cancer therapy. The ATLP nano particles were composed of an acid-responsive diblock copolymer as a sheddable matrix and an iRGD-modified polymeric prodrug of doxorubicin (iPDOX) as an amphiphilic core. A PEG corona, of the polymer matrix protected the iRGD ligand from serum degradation and nonspecific interactions with the normal tissues while circulating in the blood: The ATLP nanoparticles specifically accumulated at the tumor site through the enhanced permeability and retention (EPR) effect, followed by acid-triggered dissociation of the polymer matrix within the tumoral acidic microenvironment (pH similar to 6.8) and subsequently exposing the iRGD ligand for facilitating tumor penetration and cellular uptake of the PDOX prodrug. Additionally, the acid-triggered dissociation of the polymer matrix induced a 4.5-fold increase of the fluorescent signal for monitoring nanoparticle activation in vivo. Upon near-infrared (NIR) laser irradiation, activation of Ce6-induced significant reactive oxygen species (ROS) generation, promoted drug diffusion inside the tumor mass and circumvented the acquired drug resistance by altering the gene expression profile of the tumor cells. The ATLP strategy might provide a novel insight for cancer nanomedicine. |
| WOS关键词 | GENE DELIVERY ; BREAST-CANCER ; DOXORUBICIN RESISTANCE ; PENETRATING PEPTIDE ; COMBINATION THERAPY ; RESPONSIVE MICELLES ; TARGETED THERAPY ; PH ; REVERSAL ; MICROENVIRONMENT |
| 资助项目 | Merck Millipore[00000000] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; National Basic Research Program of China[2013CB932704] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000411043500037 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272497]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Tingting,Wang, Dangge,Liu, Jianping,et al. Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors[J]. NANO LETTERS,2017,17(9):5429-5436. |
| APA | Wang, Tingting.,Wang, Dangge.,Liu, Jianping.,Feng, Bing.,Zhou, Fangyuan.,...&Li, Yaping.(2017).Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors.NANO LETTERS,17(9),5429-5436. |
| MLA | Wang, Tingting,et al."Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors".NANO LETTERS 17.9(2017):5429-5436. |
入库方式： OAI收割
来源：上海药物研究所
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