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Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy

文献类型：期刊论文

作者He, Xinyu1,2,3; Cao, Haiqiang1,2,3; Wang, Hong1,2,3; Tan, Tao1,2; Yu, Haijun1,2; Zhang, Pengcheng1,2; Yin, Qi1,2; Zhang, Zhiwen1,2; Li, Yaping1,2
刊名NANO LETTERS
出版日期2017-09
卷号17期号:9页码:5546-5554
关键词Monocyte bioinspired nanoparticles protease cancer metastasis
ISSN号1530-6984
DOI10.1021/acs.nanolett.7b02330
文献子类Article
英文摘要Metastasis causes high mortality of breast cancer, and the inability of drug delivery to metastatic sites remains a crucial challenge for antimetastasis therapy. Herein, we report that inflammatory monocytes loading legumain-activated nanoparticles can actively target lung metastases and initiate metastasis-specific intelligent drug release for antimetastasis therapy. The cytotoxic mertansine is conjugated to poly(styrene-co-maleic anhydride) with a legumain-sensitive peptide and self-assembled into nanoparticles (SMNs), and then loaded into inflammatory monocytes to prepare the SMNs-loaded monocytes delivery system (M-SMNs). M-SMNs would be in living state in circulation to ensure their active targeting to lung metastases, and responsively damaged at the metastatic sites upon the differentiation of monocytes into macrophages. The anticancer drugs are intelligently released from M-SMNs as free drug molecules and drug-loaded microvesicles, resulting in considerable inhibition on the proliferation, migration, and invasion activities of metastatic 4T1 breast cancer cells. Moreover, M-SMNs significantly improve the delivery to lung metastases and penetrate the metastatic tumors, thus producing a 77.8% inhibition of lung metastases. Taken together, our findings provide an intelligent biomimetic drug delivery strategy via the biological properties of inflammatory monocytes for effective antimetastasis therapy.
WOS关键词MESENCHYMAL STEM-CELLS ; TUMOR-ASSOCIATED MACROPHAGES ; BREAST-CANCER METASTASIS ; IN-VIVO ; DELIVERY ; NANOMEDICINE ; MEMBRANE ; NANOGHOSTS ; STRATEGIES ; MICELLES
资助项目National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81630052] ; Youth Innovation Promotion Association of CAS[00000000]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000411043500054
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/272498]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 He, Xinyu,Cao, Haiqiang,Wang, Hong,et al. Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy[J]. NANO LETTERS,2017,17(9):5546-5554.
APA He, Xinyu.,Cao, Haiqiang.,Wang, Hong.,Tan, Tao.,Yu, Haijun.,...&Li, Yaping.(2017).Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy.NANO LETTERS,17(9),5546-5554.
MLA He, Xinyu,et al."Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy".NANO LETTERS 17.9(2017):5546-5554.

入库方式： OAI收割

来源：上海药物研究所

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