Hyaluronic acid conjugation facilitates clearance of intracellular bacterial infections by streptomycin with neglectable nephrotoxicity
文献类型：期刊论文
| 作者 | Qiu, Yuanhao1; Hou, Yilin1; Sun, Feifei1; Chen, Peng1; Wang, Dongdong1; Mu, Haibo1; Zhang, Xiaoli1; Ding, Kan2 ; Duan, Jinyou1
|
| 刊名 | GLYCOBIOLOGY
 |
| 出版日期 | 2017-09 |
| 卷号 | 27期号:9页码:861-867 |
| 关键词 | CD44 hyaluronic acid intracellular bacterial infections streptomycin |
| ISSN号 | 0959-6658 |
| DOI | 10.1093/glycob/cwx061 |
| 文献子类 | Article |
| 英文摘要 | Antibiotics such as beta-lactams and aminoglycosides are often subtherapeutic to intracellular infections due to their high hydrophilicity, resulting in low effectiveness against intracellular pathogens and the emergence of antibiotic resistance. Here we reported that an endogenous aminoglycan, hyaluronic acid could be an effective carbohydrate carrier of the aminoglycoside antibiotic, streptomycin against intracellular pathogens. This conjugation could enhance phagocytic activity, and facilitated the entry of streptomycin into host cells via a CD44-mediated pathway. It appeared that this conjugate could clear intracellular bacteria in phagocytic or nonphagocytic cells in a short-term therapy (4 h) at a lower effective dose. In addition, this conjugate was more efficient in reducing bacteria burden in an in vivo acute infection model than streptomycin did. Interestingly, subcutaneous injection of this conjugate at an excess amount had undetectable side effects such as nephrotoxicity. These results suggested that hyaluronic acid might be an efficient Trojan horse for the delivery of hydrophilic antibiotics to deal with intracellular infections. |
| WOS关键词 | N-DEACETYLATION ; DRUG-DELIVERY ; ANTIBIOTICS ; EXPRESSION ; AMINOGLYCOSIDES ; NANOPARTICLES ; CAPACITY ; DISEASES ; WATER |
| 资助项目 | National Natural Science Foundation of China (NSFC)[31570799] ; Fundamental Research Funds for the Central Universities[00000000] ; Northwest AF University[2452017026] ; Northwest AF University[Z109021713] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica[SIMM1705KF-16] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000409143900008 |
| 出版者 | OXFORD UNIV PRESS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272507]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Duan, Jinyou |
| 作者单位 | 1.Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Shaanxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Yuanhao,Hou, Yilin,Sun, Feifei,et al. Hyaluronic acid conjugation facilitates clearance of intracellular bacterial infections by streptomycin with neglectable nephrotoxicity[J]. GLYCOBIOLOGY,2017,27(9):861-867. |
| APA | Qiu, Yuanhao.,Hou, Yilin.,Sun, Feifei.,Chen, Peng.,Wang, Dongdong.,...&Duan, Jinyou.(2017).Hyaluronic acid conjugation facilitates clearance of intracellular bacterial infections by streptomycin with neglectable nephrotoxicity.GLYCOBIOLOGY,27(9),861-867. |
| MLA | Qiu, Yuanhao,et al."Hyaluronic acid conjugation facilitates clearance of intracellular bacterial infections by streptomycin with neglectable nephrotoxicity".GLYCOBIOLOGY 27.9(2017):861-867. |
入库方式： OAI收割
来源：上海药物研究所
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