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  4. 天然药物化学研究室
Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla

文献类型：期刊论文

作者Ye, Fei2,4; Zhu, Zheng-Dan2,4; Chen, Jun-Sheng1; Li, Jing1; Gu, Yu-Cheng3; Zhu, Wei-Liang2,4; Li, Xu-Wen4; Guo, Yue-Wei2,4
刊名ORGANIC LETTERS
出版日期2017-08-18
卷号19期号:16页码:4183-4186
ISSN号1523-7060
DOI10.1021/acs.orglett.7b01716
文献子类Article
英文摘要Three new diterpenes, xishacorenes A-C, featuring an undescribed bicyclo[3.3.1]nonane nucleus bearing 1-vinyl and 13-[(E)-4-methylpenta-1,3-dien-1-yl] alkyl chains, and a related monocyclic known compound, were isolated from the Xisha soft coral Sinularia polydactyla. The structures of xishacorenes A-C, including their absolute configurations, were elucidated by extensive spectroscopic analysis and TDDFT ECD calculations. The new compounds exhibit an interesting dose-dependent promotion effect on the ConA-induced T lymphocyte proliferation. A plausible biosynthetic pathway of xishacorenes A-C is proposed.
WOS关键词POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS ; SESQUITERPENOIDS ; TERPENOIDS ; DEPRESSA
资助项目Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[41676073] ; Natural Science Foundation of China[81603022] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM 1705ZZ-01] ; "Youth Innovation Promotion Association" from Chinese Academy of Sciences[2016258] ; "Young Elite Scientists Sponsorship" from China Association for Science and Technology[2016QNRC001] ; Shanghai "Pujiang Program"[16PJ1410600] ; Syngenta-SIMM-PhD Studentship Project[00000000]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000408285600008
源URL[http://119.78.100.183/handle/2S10ELR8/272524]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, 5 Yu Shan Rd, Qingdao 266003, Peoples R China;
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
3.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Ye, Fei,Zhu, Zheng-Dan,Chen, Jun-Sheng,et al. Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla[J]. ORGANIC LETTERS,2017,19(16):4183-4186.
APA Ye, Fei.,Zhu, Zheng-Dan.,Chen, Jun-Sheng.,Li, Jing.,Gu, Yu-Cheng.,...&Guo, Yue-Wei.(2017).Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla.ORGANIC LETTERS,19(16),4183-4186.
MLA Ye, Fei,et al."Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla".ORGANIC LETTERS 19.16(2017):4183-4186.

入库方式： OAI收割

来源：上海药物研究所

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