G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin
文献类型：期刊论文
| 作者 | Wang, Ya-fang1,3; Zhang, Jie4; Su, Yi3; Shen, Yan-yan3; Jiang, Dong-xian2; Hou, Ying-yong2; Geng, Mei-yu3 ; Ding, Jian3; Chen, Yi3
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017-08-17 |
| 卷号 | 8 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-017-00350-9 |
| 文献子类 | Article |
| 英文摘要 | G9a, a H3K9 methyltransferase, shows elevated expression in many types of human cancers, particularly breast cancer. However, the tumorigenic mechanism of G9a is still far from clear. Here we report that G9a exerts its oncogenic function in breast cancer by repressing hephaestin and destruction cellular iron homeostasis. In the case of pharmacological inhibition or short hairpin RNA interference-mediated suppression of G9a, the expression and activity of hephaestin increases, leading to the observed decrease of intracellular labile iron content and the disturbance of breast cancer cell growth in vitro and in vivo. We also provide evidence that G9a interacts with HDAC1 and YY1 to form a multi-molecular complex that contributes to hephaestin silencing. Furthermore, high G9a expression and low hephaestin expression correlate with poor survival of breast cancer are investigated. All these suggest a G9a-dependent epigenetic program in the control of iron homeostasis and tumor growth in breast cancer. |
| WOS关键词 | H3K9 METHYLTRANSFERASE G9A ; NEGATIVE REGULATION ; EXPRESSION ; CELLS ; PROLIFERATION ; CERULOPLASMIN ; METABOLISM ; CHELATORS ; TRANSPORT ; PROTEINS |
| 资助项目 | National Natural Science Foundation of China[81273545] ; National Natural Science Foundation of China[81521005] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000407864900002 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272526]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Geng, Mei-yu; Ding, Jian; Chen, Yi |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol,CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Ya-fang,Zhang, Jie,Su, Yi,et al. G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin[J]. NATURE COMMUNICATIONS,2017,8. |
| APA | Wang, Ya-fang.,Zhang, Jie.,Su, Yi.,Shen, Yan-yan.,Jiang, Dong-xian.,...&Chen, Yi.(2017).G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin.NATURE COMMUNICATIONS,8. |
| MLA | Wang, Ya-fang,et al."G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin".NATURE COMMUNICATIONS 8(2017). |
入库方式： OAI收割
来源：上海药物研究所
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