Difluorination of Furonaphthoquinones
文献类型：期刊论文
| 作者 | Li, Jie1; Xue, Yu2; Fan, Zhoulong3,4,5; Ding, Chunyong3,5 ; Zhang, Ao1,3,4,5
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2017-07-21 |
| 卷号 | 82期号:14页码:7388-7393 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.7b01064 |
| 文献子类 | Article |
| 英文摘要 | An unprecedented difluorination reaction was developed based on the furonaphthoquinone skeleton of natural products tanshinones and their analogues. By using Selectfluor as the fluorinating source and H2O as the hydroxyl source, a wide range of unique polycyclic alpha,alpha-difluoro beta,beta-dihydroxyl para-quinone products were achieved with yields up to 90%. The mechanistic studies revealed that the reaction might undergo tandem multiple electrophilic and nucleophilic substitutions, as well as cleavages of C-O and C-C bonds. This approach not only provides a new method to synthesis of alpha,alpha-difluoro ketones, but also affords a series of unique chemotypes for biological activity screening. |
| WOS关键词 | PRODUCT TANSHINONE IIA ; DIFLUOROMETHYL KETONES ; MEDICINAL CHEMISTRY ; SALVIA-MILTIORRHIZA ; CARBONYL-COMPOUNDS ; ACID-CHLORIDES ; PLASMEPSIN II ; DERIVATIVES ; INHIBITORS ; FLUORINE |
| 资助项目 | National Natural Science Foundation of China[81373277] ; National Natural Science Foundation of China[81402790] ; International Cooperative Program[GJHZ1622] ; Frontier Science of the Chinese Academy of Sciences[160621] ; Shanghai Commission of Science and Technology[16XD1404600] ; Shanghai Commission of Science and Technology[14431905300] ; Shanghai Commission of Science and Technology[14431900400] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000406355900031 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272560]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, Chunyong; Zhang, Ao |
| 作者单位 | 1.ShanghaiTech Univ, Shanghai 201210, Peoples R China; 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jie,Xue, Yu,Fan, Zhoulong,et al. Difluorination of Furonaphthoquinones[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(14):7388-7393. |
| APA | Li, Jie,Xue, Yu,Fan, Zhoulong,Ding, Chunyong,&Zhang, Ao.(2017).Difluorination of Furonaphthoquinones.JOURNAL OF ORGANIC CHEMISTRY,82(14),7388-7393. |
| MLA | Li, Jie,et al."Difluorination of Furonaphthoquinones".JOURNAL OF ORGANIC CHEMISTRY 82.14(2017):7388-7393. |
入库方式： OAI收割
来源：上海药物研究所
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