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Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes

文献类型：期刊论文

作者Fan, Zhoulong1,2,3; Lu, Heng4; Li, Wei2,3; Geng, Kaijun1,2,3; Zhang, Ao1,2,3,4
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
出版日期2017-07-21
卷号15期号:27页码:5701-5708
ISSN号1477-0520
DOI10.1039/c7ob01271c
文献子类Article
英文摘要A switchable synthesis of N-substituted indole derivatives from phenidones via rhodium-catalyzed redox-neutral C-H activation has been achieved. In this protocol, we firstly disclosed that the reactivity of Rh(III) catalysis could be enhanced through employing palladium acetate as an additive. Some representative features include external oxidant-free, applicable to terminal alkynes, short reaction time and operational simplicity. The utility of this method is further showcased by the economical synthesis of potent anticancer PARP-1 inhibitors.
WOS关键词C-H ACTIVATION ; N-N BOND ; OXIDIZING DIRECTING GROUP ; OXYGEN-ATOM TRANSFER ; EFFICIENT SYNTHESIS ; REGIOSELECTIVE SYNTHESIS ; INTERNAL ALKYNES ; RHODIUM(III)-CATALYZED SYNTHESIS ; SUBSTITUTED INDOLES ; DIAZO-COMPOUNDS
资助项目Chinese NSF[81373277] ; Chinese NSF[81430080] ; National Program on Key Basic Research Project of China[2015CB910603] ; International Cooperative Program[GJHZ1622] ; Chinese Academy of Sciences[160621] ; Shanghai Commission of Science and Technology[16XD1404600] ; Shanghai Commission of Science and Technology[14431905300] ; Shanghai Commission of Science and Technology[14431900400] ; CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YKF-08] ; CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YZZ-06]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000405482000008
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/272561]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhang, Ao
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
2.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.ShanghaiTech Univ, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Zhoulong,Lu, Heng,Li, Wei,et al. Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(27):5701-5708.
APA Fan, Zhoulong,Lu, Heng,Li, Wei,Geng, Kaijun,&Zhang, Ao.(2017).Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes.ORGANIC & BIOMOLECULAR CHEMISTRY,15(27),5701-5708.
MLA Fan, Zhoulong,et al."Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes".ORGANIC & BIOMOLECULAR CHEMISTRY 15.27(2017):5701-5708.

入库方式： OAI收割

来源：上海药物研究所

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