Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose
文献类型：期刊论文
| 作者 | Zhang, Jing1; Li, Huating1; Zhou, Hu2 ; Fang, Li2; Xu, Jingjing2; Yan, Han1; Chen, Shuqin1; Song, Qianqian1; Zhang, Yinan6,7; Xu, Aimin4,5
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-07-20 |
| 卷号 | 7 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-06252-6 |
| 文献子类 | Article |
| 英文摘要 | The gut-derived hormone Fibroblast growth factor 19 (FGF19) could regulate glucose metabolism and is induced by bile acids (BAs) through activating Farnesoid X Receptor (FXR). FGF19 was found to decrease in subjects with isolated-impaired fasting glucose (I-IFG) and type 2 diabetes mellitus (T2DM). However, the reason for the change of FGF19 in subjects with different glucometabolic status remained unclear. Here we measured six BAs including chenodeoxycholic acid (CDCA), cholic acid, deoxycholic acid, their glycine conjugates and FGF19 levels during oral glucose tolerance test (OGTT) in normal glucose tolerance (NGT), isolated-impaired glucose tolerance, I-IFG, combined glucose intolerance (CGI) and T2DM subjects. After OGTT, serum FGF19 peaked at 120 min in all subjects. Glycine conjugated BAs peaked at 30 min, while free BAs did not elevated significantly. Consistent with the decrease trend in FGF19 levels, fasting serum CDCA levels in subjects with I-IFG, CGI and T2DM were significantly lower than NGT subjects (P < 0.05). Fasting serum CDCA was independently associated with FGF19. CDCA strongly upregulated FGF19 mRNA levels in LS174T cells in a dose-and time-dependent manner. These results suggest that the decrease of FGF19 in subjects with I-IFG was at least partially due to their decrease of CDCA acting via FXR. |
| WOS关键词 | FARNESOID-X-RECEPTOR ; BILE-SALT HYDROLASE ; PLASMA-GLUCOSE ; DIURNAL-VARIATION ; METABOLIC-RATE ; OBESE-PATIENTS ; HOMEOSTASIS ; HUMANS ; FGF19 ; MICE |
| 资助项目 | National Natural Science Foundation major international (regional) joint research project[81220108006] ; Shanghai Natural Science Foundation[15ZR1431700] ; Young Scientists Fund of National Natural Science Foundation of China[81200292] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000405907800096 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272562]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Fang, Qichen; Ye, Yang; Jia, Weiping |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Key Lab Diabet Mellitus, Dept Endocrinol & Metab, Shanghai Diabet Inst,Shanghai Clin Ctr Diabet,Aff, Shanghai 200233, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Univ Hong Kong, Dept Med, State Key Lab Pharmaceut Biotechnol, Hong Kong 999077, Hong Kong, Peoples R China; 5.Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong 999077, Hong Kong, Peoples R China; 6.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China; 7.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Ctr Translat Med, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Li, Huating,Zhou, Hu,et al. Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Zhang, Jing.,Li, Huating.,Zhou, Hu.,Fang, Li.,Xu, Jingjing.,...&Jia, Weiping.(2017).Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose.SCIENTIFIC REPORTS,7. |
| MLA | Zhang, Jing,et al."Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。