Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells
文献类型：期刊论文
| 作者 | Xu, Ya-Ming1; Wijeratne, E. M. Kithsiri1; Babyak, Ashley L.2,3; Marks, Hanna R.2,3; Brooks, Alan D.2,3; Tewary, Poonam2,3; Xuan, Li-Jiang4 ; Wang, Wen-Qiong4; Sayers, Thomas J.2,3; Gunatilaka, A. A. Leslie1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2017-07 |
| 卷号 | 80期号:7页码:1981-1991 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b01129 |
| 文献子类 | Article |
| 英文摘要 | Investigation,of aeroponically grown Physalis peruviana resulted in the isolation of 11 new withanolides, including perulactones I-L 17-deoxy-23l-hydroxywithanolide E (5), 23 beta-hydroxywithanolide E (6), 4-deoxyphyperunolide A (7), 7 beta-hydroxywithanolide F (8), 7 beta-hydroxy-17-epi-withanolide K (9), 24,25-dihydro-23 beta,28-dihydroxywithanolide G (10), and 24,25-dihydrowithanolide E (11), together with 14 known withanolides (12-25). The structures of 1-11 were elucidated by the analysis of their spectroscopic data, and 12-25 were identified by comparison of their spectroscopic data with those reported. All withanolides were evaluated for their cytotoxic activity against a panel of tumor cell lines including LNCaP (androgen -sensitive human prostate adenocarcinoma), 22Rv1 (androgen -resistant human prostate adenocarcinoma), ACHN (human renal adenocarcinoma), M14 (human melanoma), SK-MEL-28 (human melanoma), and normal human foreskin fibroblast cells. Of these, the 17 beta-hydroxywithanolides (17-BHWs) 6, 8, 9, 11-13, 15, and 19-22 showed selective cytotoxic activity against the two prostate cancer cell lines LNCaP and 22Rv1, whereas 13 and 20 exhibited selective toxicity for the ACHN renal carcinoma cell line. These cytotoxiCity data provide additional structure activity relationship information for the 17-BHWS. |
| WOS关键词 | 4-BETA-HYDROXYWITHANOLIDE E ; WITHANIA-SOMNIFERA ; DNA-DAMAGE ; SIDE-CHAIN ; APOPTOSIS ; THERAPY ; CONSTITUENTS ; ACTIVATION ; DISCOVERY ; PROTEINS |
| 资助项目 | College of Agriculture and Life Sciences[00000000] ; School of Natural Resources[00000000] ; Environment of the University of Arizona[00000000] ; National Cancer Institute, National Institutes of Health[HHSN26120080001E] ; NIH, Frederick National Lab, Center for Cancer Research[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000406818300004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272577]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gunatilaka, A. A. Leslie |
| 作者单位 | 1.Univ Arizona, Sch Nat Resources & Environm, Coll Agr & Life Sci, Nat Prod Ctr, 250 E Valencia Rd, Tucson, AZ 85706 USA; 2.Leidos Biomed Res Inc, Basic Res Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA; 3.NCI, Canc & Inflammat Program, Frederick, MD 21702 USA; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ya-Ming,Wijeratne, E. M. Kithsiri,Babyak, Ashley L.,et al. Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):1981-1991. |
| APA | Xu, Ya-Ming.,Wijeratne, E. M. Kithsiri.,Babyak, Ashley L..,Marks, Hanna R..,Brooks, Alan D..,...&Gunatilaka, A. A. Leslie.(2017).Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.JOURNAL OF NATURAL PRODUCTS,80(7),1981-1991. |
| MLA | Xu, Ya-Ming,et al."Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells".JOURNAL OF NATURAL PRODUCTS 80.7(2017):1981-1991. |
入库方式： OAI收割
来源：上海药物研究所
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