Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo
文献类型：期刊论文
| 作者 | Liu, Rongxia1; Heiss, Elke H.5; Schachner, Daniel5; Jiang, Baohong4 ; Liu, Wanhui1; Breuss, Johannes M.3; Dirsch, Verena M.5; Atanasov, Atanas G.2,5
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2017-07 |
| 卷号 | 80期号:7页码:2146-2150 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.7b00268 |
| 文献子类 | Article |
| 英文摘要 | Xanthohumol (1) is a principal prenylated chalcone found in hops. The aim of this study was to examine its influence on platelet-derived growth factor (PDGF)-BB-triggered vascular smooth muscle cell (VSMC) proliferation and migration in vitro and on experimentally induced neointima formation in vivo. Quantification of resazurin conversion indicated that 1 can inhibit PDGF-BB-induced VSMC proliferation concentration-dependently (IC50 = 3.49 mu M). Furthermore, in a wound-healing assay 1 potently suppresses PDGF-BB-induced VSMC migration at 15 mu M. Tested in a mouse femoral artery cuff model, 1 significantly reduces neointima formation. Taken together, we show that 1 represses PDGF-BB-induced VSMC proliferation and migration in vitro as well as neointima formation in vivo. This novel activity suggests 1 as an interesting candidate for further studies addressing a possible therapeutic application to counteract vascular proliferative disease. |
| WOS关键词 | HUMULUS-LUPULUS ; PHARMACOLOGICAL PROFILE ; CARDIOVASCULAR-DISEASE ; INDIRUBIN-3'-MONOXIME ; ATHEROSCLEROSIS ; INFLAMMATION ; POLYPHENOLS ; SUPPRESSION ; INHIBITION ; ACTIVATION |
| 资助项目 | National Natural Science Foundation of China[81603326] ; European Union Seventh Framework Program (EU-FP7) Marie Curie Fellowship[252881] ; European Union Seventh Framework Program (EU-FP7) Marie Curie Fellowship[909881] ; Austrian Science Fund (FWF)[P2S971-B23] ; Polish KNOW (Leading National Research Centre) Scientific Consortium "Healthy Animal-Safe Food", Ministry of Science and Higher Education[05-1/KNOW2/2015] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000406818300025 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272580]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Heiss, Elke H.; Atanasov, Atanas G. |
| 作者单位 | 1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; 2.Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Poland 3.Med Univ Vienna, Inst Vasc Biol & Thrombosis Res, Ctr Physiol & Pharmacol, A-1090 Vienna, Austria; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria; |
| 推荐引用方式 GB/T 7714 | Liu, Rongxia,Heiss, Elke H.,Schachner, Daniel,et al. Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):2146-2150. |
| APA | Liu, Rongxia.,Heiss, Elke H..,Schachner, Daniel.,Jiang, Baohong.,Liu, Wanhui.,...&Atanasov, Atanas G..(2017).Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo.JOURNAL OF NATURAL PRODUCTS,80(7),2146-2150. |
| MLA | Liu, Rongxia,et al."Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo".JOURNAL OF NATURAL PRODUCTS 80.7(2017):2146-2150. |
入库方式： OAI收割
来源：上海药物研究所
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