Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine
文献类型：期刊论文
| 作者 | Liu, Haichao1; Zhang, Xiwu1; Shan, Dong1; Pitchakuntla, Mallesham1; Ma, Yongfan1; Jia, Yanxing1,2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2017-06-16 |
| 卷号 | 19期号:12页码:3323-3326 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.7b01504 |
| 文献子类 | Article |
| 英文摘要 | A new approach for the divergent total synthesis of eight ergot alkaloids is reported. The approach allows the first total syntheses of pyroclavine, pibocin A, 9-deacetoxyfumigaclavine C, and fumigaclavine G and also enables the efficient synthesis of festuclavine, costaclavine, epi-costaclavine, and dihydrosetoclavine. The main feature of the synthesis is the use of an unprecedented Pd-catalyzed intramolecular Larock indole annulation/TsujiTrost allylation cascade to assemble the tetracyclic core in one step. |
| WOS关键词 | ENDOPHYTIC ASPERGILLUS-FUMIGATUS ; LAROCK INDOLE SYNTHESIS ; ERGOT ALKALOIDS ; CLAVINE ALKALOIDS ; LYSERGIC-ACID ; (+)-LYSERGIC ACID ; CLAVICIPITIC ACID ; 2,3-DISUBSTITUTED INDOLES ; TRICYCLIC INDOLES ; INTERNAL ALKYNES |
| 资助项目 | National Natural Science Foundation of China[21372017] ; National Natural Science Foundation of China[21402003] ; National Natural Science Foundation of China[21290183] ; National Natural Science Foundation of China[21572008] ; State Key Laboratory of Drug Research[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000403854300072 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272605]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Jia, Yanxing |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Haichao,Zhang, Xiwu,Shan, Dong,et al. Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine[J]. ORGANIC LETTERS,2017,19(12):3323-3326. |
| APA | Liu, Haichao,Zhang, Xiwu,Shan, Dong,Pitchakuntla, Mallesham,Ma, Yongfan,&Jia, Yanxing.(2017).Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine.ORGANIC LETTERS,19(12),3323-3326. |
| MLA | Liu, Haichao,et al."Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine".ORGANIC LETTERS 19.12(2017):3323-3326. |
入库方式： OAI收割
来源：上海药物研究所
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