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Cytotoxic sesquiterpene lactones from Artemisia anomala

文献类型：期刊论文

作者Li, Lu1,2; Liu, Hongchun3; Tang, Chunping2; Yao, Sheng2; Ke, Changqiang2; Xu, Chenghui3; Ye, Yang2,4
刊名PHYTOCHEMISTRY LETTERS
出版日期2017-06
卷号20页码:177-180
关键词Artemisia anomala Compositae Sesquiterpene lactones Structure elucidation Cytotoxicity
ISSN号1874-3900
DOI10.1016/j.phytol.2017.04.038
文献子类Article
英文摘要Two new sesquiterpene lactones, 8 alpha-acetoxy-1,10 alpha-epoxy-2-oxo-guaia-3,11(13)-dien-12,6 alpha-olide (1) and 13-acetoxy- 1-oxo-4 alpha-hydroxy-eudesman-2(11)-dien-12,6 alpha-olide (2), along with six known analogs (3-8), were isolated from the whole plant of Artemisia anomala S. Moore. Their structures were elucidated by extensive analysis of spectroscopic data. Compounds 6 and 7 exhibited in vitro moderate cytotoxicity against A549 cells with IC50 values of 0.6 and 0.9 mu M, and HepG2 cells with IC50 values of 5.4 and 3.0 mu M, respectively.
WOS关键词FARNESYL-PROTEIN TRANSFERASE ; NF-KAPPA-B ; DIMERIC GUAIANOLIDES ; INHIBITORS ; ARTEMINOLIDE ; SYLVATICA
资助项目National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds of China[81673327] ; Youth Innovation Promotion Association CAS[00000000] ; Chinese Academy of Sciences[GJHZ1678] ; Chinese Academy of Sciences[GJHZ1739]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000405467600035
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/272626]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Ye, Yang
作者单位1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China;
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lu,Liu, Hongchun,Tang, Chunping,et al. Cytotoxic sesquiterpene lactones from Artemisia anomala[J]. PHYTOCHEMISTRY LETTERS,2017,20:177-180.
APA Li, Lu.,Liu, Hongchun.,Tang, Chunping.,Yao, Sheng.,Ke, Changqiang.,...&Ye, Yang.(2017).Cytotoxic sesquiterpene lactones from Artemisia anomala.PHYTOCHEMISTRY LETTERS,20,177-180.
MLA Li, Lu,et al."Cytotoxic sesquiterpene lactones from Artemisia anomala".PHYTOCHEMISTRY LETTERS 20(2017):177-180.

入库方式： OAI收割

来源：上海药物研究所

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