Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects
文献类型：期刊论文
| 作者 | Hu, Chang-Ling1; Xiong, Juan1; Wang, Pei-Pei2 ; Ma, Guang-Lei1; Tang, Yu1; Yang, Guo-Xun1; Li, Jia2; Hu, Jin-Feng1
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2017-06 |
| 卷号 | 20页码:239-245 |
| 关键词 | Pinus kwangtungensis Pinaceae Endangered plant Diterpenoids PTP1B inhibition |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2017.05.006 |
| 文献子类 | Article |
| 英文摘要 | Pinus kwangtungensis is an endangered pine species native to China. In the present study, 15 diterpenoids including three new labdane-type analogs were isolated and characterized during a pioneer phytochemical investigation on a mass-limited sample of the needles and twigs of this plant, which is growing in a Cantonese garden. The new structures, (4S, 5R, 9S, 10R)-6-oxo-labd-7,13-dien-16,15-olid-19-oic acid (1), 15(S)-n-butoxypinusolidic acid (2), and beta-D-glucopyranosyl-(4S, 5R, 9S, 10R)-labda-8(17), 13-dien-15,16-olid-19-oate (3), were established by extensive spectroscopic methods and some chemical transformations. Among the isolates, lambertianic acid (10) and cassipourol (15) showed inhibitory activities against human protein tyrosine phosphatase 1 B (PTP1B), a target for the treatment of type-II diabetes and obesity, with IC50 values of 25.5 and 11.2 mu M, respectively. |
| WOS关键词 | PLANT CHLORANTHUS-OLDHAMII ; ARALIA-CONTINENTALIS ROOTS ; TYROSINE-PHOSPHATASE 1B ; C-13 NMR DATA ; LABDANE DITERPENES ; ABIES-GEORGEI ; LEAVES ; ORIENTALIS ; ACID ; FORMOSANA |
| 资助项目 | NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; National Basic Research Program of China (973 Program)[2013CB530700] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000405467600048 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272627]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Xiong, Juan; Hu, Jin-Feng |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Chang-Ling,Xiong, Juan,Wang, Pei-Pei,et al. Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects[J]. PHYTOCHEMISTRY LETTERS,2017,20:239-245. |
| APA | Hu, Chang-Ling.,Xiong, Juan.,Wang, Pei-Pei.,Ma, Guang-Lei.,Tang, Yu.,...&Hu, Jin-Feng.(2017).Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects.PHYTOCHEMISTRY LETTERS,20,239-245. |
| MLA | Hu, Chang-Ling,et al."Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects".PHYTOCHEMISTRY LETTERS 20(2017):239-245. |
入库方式： OAI收割
来源：上海药物研究所
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