Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER
文献类型：期刊论文
| 作者 | Liang, Lin-Fu1,2; Chen, Wen-Ting2; Mollo, Ernesto3; Yao, Li-Gong2; Wang, He-Yao2 ; Xiao, Wei4; Guo, Yue-Wei2
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2017-06 |
| 卷号 | 14期号:6 |
| 关键词 | Terpenoids Soft coral Sarcophyton trocheliophorum Structure elucidation PTP1B inhibitory activities |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.201700079 |
| 文献子类 | Article |
| 英文摘要 | Minor metabolic components, six new cembranoids sarcophytrols G -L (1 -6) along with two known related analogues 7 and 8, were isolated from the South China Sea soft coral Sarcophyton trocheliophorum. Their structures were elucidated by extensive spectroscopic analyses (1D-, 2D-NMR, and ESI-MS) as well as comparison with literature data. As part of our ongoing research project for discovering bioactive substances from Chinese marine invertebrates, compounds 1 -8 were tested for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of Type-II diabetes and obesity. However, none of them exhibited potent PTP1B inhibitory activities. |
| WOS关键词 | LOBOPHYTUM-CRASSUM ; SINULARIA-RIGIDA ; PTP1B INHIBITORS ; CEMBRANOIDS ; DITERPENOIDS ; PHOSPHATASE |
| 资助项目 | National Natural Science Foundation of China[81520108028] ; National Natural Science Foundation of China[41506187] ; National Natural Science Foundation of China[21672230] ; National Natural Science Foundation of China[41676073] ; National Natural Science Foundation of China[81603022] ; SCTSM Project[15431901000] ; SCTSM Project[14431901100] ; Hunan Provincial Natural Science Foundation of China[2015JJ3176] ; Scientific Research Fund of Hunan Provincial Education Department[16C1674] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; China Postdoctoral Science Foundation[2016M601677] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000405126900009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272629]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xiao, Wei; Guo, Yue-Wei |
| 作者单位 | 1.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China; 3.CNR, ICB, Via Campi Flegrei 34, IT-80078 Naples, Italy; 4.Jiangsu Kan Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Lin-Fu,Chen, Wen-Ting,Mollo, Ernesto,et al. Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER[J]. CHEMISTRY & BIODIVERSITY,2017,14(6). |
| APA | Liang, Lin-Fu.,Chen, Wen-Ting.,Mollo, Ernesto.,Yao, Li-Gong.,Wang, He-Yao.,...&Guo, Yue-Wei.(2017).Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER.CHEMISTRY & BIODIVERSITY,14(6). |
| MLA | Liang, Lin-Fu,et al."Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER".CHEMISTRY & BIODIVERSITY 14.6(2017). |
入库方式： OAI收割
来源：上海药物研究所
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