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5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities

文献类型：期刊论文

作者Xue, Duo-Qing1; Liu, Hai-Li1; Chen, Si-Han1; Mollo, Ernesto2; Gavagnin, Margherita2; Li, Jia1; Li, Xu-Wen1; Guo, Yue-Wei1
刊名CHINESE CHEMICAL LETTERS
出版日期2017-06
卷号28期号:6页码:1190-1193
关键词5-Alkylpyrrole-2-carboxaldehyde Sponge Mycale lissochela PTP1B inhibitor Marine natural product
ISSN号1001-8417
DOI10.1016/j.cclet.2017.03.040
文献子类Article
英文摘要Two new 5-alkylpyrrole-2-carboxaldehyde derivatives, mycalenitrile-15 (1) and mycalenitrile-16 (2), along with five known related ones (3-7), were isolated from the South China Sea sponge Mycale lissochela. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those reported in the literature. In bioassay, compounds 1 and 7 exhibited significant PTP1B (Protein-tyrosine phosphatase 1B, a recognized target for diabetes and obesity) inhibitory activities with IC50 values of 8.6 and 3.1 mu mol/L, respectively. A preliminary SAR analysis of the isolated compounds with their PTP1B inhibitory effects was described. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词ZEALAND MARINE SPONGE ; AXINYSSA-VARIABILIS ; MYCALAMIDE-A ; METABOLITES ; SESQUITERPENES
资助项目National Natural Science Foundation of China[41476063] ; National Natural Science Foundation of China[81520108028] ; National Natural Science Foundation of China[81273430] ; National Natural Science Foundation of China[41306130 81302692] ; National Natural Science Foundation of China[41676073] ; National Natural Science Foundation of China[81603022] ; SCTSM Project from Shanghai Science and Technology Committee, Shanghai, China[14431901100] ; SCTSM Project from Shanghai Science and Technology Committee, Shanghai, China[15431901000] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, China[CASIMM0120152039] ; SKLDR/SIMM Projects from Shanghai Institute of Materia Medica, China[SIMM 1501ZZ-03] ; "Youth Innovation Promotion Association" from Chinese Academy of Sciences[2016258] ; "Young Talent Supporting Project" from China Association for Science and Technology[2016QNRC001] ; Shanghai "Pujiang Program"[16111410600]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:6048947
WOS记录号WOS:000404696800012
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/272630]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Natl Res Council CNR, Inst Biomol Chem ICB, Via Campi Flegrei 34, I-80078 Naples, Italy
推荐引用方式
GB/T 7714		 Xue, Duo-Qing,Liu, Hai-Li,Chen, Si-Han,et al. 5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities[J]. CHINESE CHEMICAL LETTERS,2017,28(6):1190-1193.
APA Xue, Duo-Qing.,Liu, Hai-Li.,Chen, Si-Han.,Mollo, Ernesto.,Gavagnin, Margherita.,...&Guo, Yue-Wei.(2017).5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities.CHINESE CHEMICAL LETTERS,28(6),1190-1193.
MLA Xue, Duo-Qing,et al."5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities".CHINESE CHEMICAL LETTERS 28.6(2017):1190-1193.

入库方式： OAI收割

来源：上海药物研究所

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