Targeting sphingosine-1-phosphate signaling for cancer therapy
文献类型：期刊论文
| 作者 | Xie, Zuoquan1 ; Liu, Hong2; Geng, Meiyu1
|
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2017-06 |
| 卷号 | 60期号:6页码:585-600 |
| 关键词 | sphingosine-1-phosphate sphingosine ceramide cancer inflammation immunity |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-017-9046-6 |
| 文献子类 | Review |
| 英文摘要 | Sphingosine-1-phosphate (S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival, cell proliferation, cell migration, angiogenesis and many other cellular processes. S1P either activates S1P receptors (S1PR1-5) through "inside-out signaling" or acts directly on intracellular targets to regulate various cellular processes. In the past two decades, much progress has been made in exploring S1P signaling and its pathogenic roles in diseases as well as in developing modulators of S1P signaling, including S1P agonists, S1P antagonists and sphingosine kinase (SphK) inhibitors. Ceramide and S1P have been defined as reciprocal regulators of cell fate, and S1P signaling has been shown to be crucial for the pathogenesis of various diseases, including autoimmune diseases, inflammation and cancer; therefore, targeting S1P signaling may curtail the process of pathogenesis and serve as a potential therapeutic target for the treatment of these diseases. In this review, we describe recent advances in our understanding of S1P signaling in cancer development (particularly in inflammation-associated cancer) as well as in innate and adaptive immunity, and we also discuss modulators of S1P signaling in cancer treatment. |
| WOS关键词 | SPHINGOSINE KINASE 1 ; PROTEIN-COUPLED RECEPTOR ; COLITIS-ASSOCIATED CANCER ; GROWTH-FACTOR RECEPTOR ; 2 INHIBITOR ABC294640 ; GENE-DEFICIENT MICE ; B-CELL LYMPHOMA ; CHRONIC INTESTINAL INFLAMMATION ; PERSISTENT STAT3 ACTIVATION ; HEART TRANSPLANTATION MODEL |
| 资助项目 | National Natural Science Foundation of China[91229204] ; Major Project of the Chinese National Programs for Fundamental Research and Development[2015CB910304] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6041148 |
| WOS记录号 | WOS:000404775400004 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272633]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Liu, Hong; Geng, Meiyu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Zuoquan,Liu, Hong,Geng, Meiyu. Targeting sphingosine-1-phosphate signaling for cancer therapy[J]. SCIENCE CHINA-LIFE SCIENCES,2017,60(6):585-600. |
| APA | Xie, Zuoquan,Liu, Hong,&Geng, Meiyu.(2017).Targeting sphingosine-1-phosphate signaling for cancer therapy.SCIENCE CHINA-LIFE SCIENCES,60(6),585-600. |
| MLA | Xie, Zuoquan,et al."Targeting sphingosine-1-phosphate signaling for cancer therapy".SCIENCE CHINA-LIFE SCIENCES 60.6(2017):585-600. |
入库方式： OAI收割
来源：上海药物研究所
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