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Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don

文献类型：期刊论文

作者Yuan, Qing-Qing1,2; Song, Wei-Bin1; Wang, Wen-Qiong1; Xuan, Li-Jiang1
刊名FITOTERAPIA
出版日期2017-06
卷号119页码:40-44
关键词Scutellaria barbata D. Don Lamiaceae neo-Clerodane diterpenoids Cytotoxic activity
ISSN号0367-326X
DOI10.1016/j.fitote.2017.03.012
文献子类Article
英文摘要Phytochemical investigation of the 70% acetone extract of the whole plant of Scutellaria barbata D. Don afforded six new neo-clerodane diterpenoids, scubatines A-F (1-6), and four known analogues (7-10). Their structures were elucidated on the basis of extensive spectroscopic analyses. Cytotoxic activity against the HL-60 and A549 cell lines was assessed for all isolated compounds. Compound 9 exhibited moderate activity against HL-60 with an IC50 value of 5.6 mu M. Compound 6 showed weak cytotoxic activity against A549 and HL-60 with IC50 values of 10.4 and 15.3 mu M, respectively. (C) 2017 Elsevier B.V. All rights reserved.
WOS关键词COLORIMETRIC ASSAY ; ALKALOIDS
资助项目National Science & Technology major project "Key New Drug Creation and Manufacturing Program"[SIMM1601ZZ-03]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000404307800007
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/272635]  
专题上海中药现代化研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Xuan, Li-Jiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China;
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Qing-Qing,Song, Wei-Bin,Wang, Wen-Qiong,et al. Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don[J]. FITOTERAPIA,2017,119:40-44.
APA Yuan, Qing-Qing,Song, Wei-Bin,Wang, Wen-Qiong,&Xuan, Li-Jiang.(2017).Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don.FITOTERAPIA,119,40-44.
MLA Yuan, Qing-Qing,et al."Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don".FITOTERAPIA 119(2017):40-44.

入库方式： OAI收割

来源：上海药物研究所

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