Low, but not high, dose caffeine is a readily available probe for adenosine actions
文献类型：期刊论文
| 作者 | Fredholm, Bertil B.1; Yang, Jiangning1,2; Wang, Yingqing1,3
|
| 刊名 | MOLECULAR ASPECTS OF MEDICINE
 |
| 出版日期 | 2017-06 |
| 卷号 | 55页码:20-25 |
| 关键词 | Adenosine Caffeine Theophylline Heart rate Locomotion |
| ISSN号 | 0098-2997 |
| DOI | 10.1016/j.mam.2016.11.011 |
| 文献子类 | Review |
| 英文摘要 | Caffeine is very widely used and knowledge of its mode of action can be used to gain an understanding of basal physiological regulation. This review makes the point that caffeine is - in low doses - an antagonist of adenosine acting at A(1), A(2A) and A(2B) receptors. We use published and unpublished data to make the point that high dose effects of caffeine are not only qualitatively different but have a different underlying mechanism. Therefore one must be careful in only using epidemiological or experimental data where rather low doses of caffeine are used to draw conclusions about the physiology and pathophysiology of adenosine. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | COFFEE CONSUMPTION ; INTERNATIONAL UNION ; A(2A) RECEPTORS ; RISK ; METAANALYSIS ; BRAIN ; A(1) ; CLASSIFICATION ; ALKYLXANTHINES ; POLYMORPHISMS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000404013000004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272640]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Fredholm, Bertil B. |
| 作者单位 | 1.Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden; 2.Karolinska Inst, Dept Med, Div Cardiol, Stockholm, Sweden; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fredholm, Bertil B.,Yang, Jiangning,Wang, Yingqing. Low, but not high, dose caffeine is a readily available probe for adenosine actions[J]. MOLECULAR ASPECTS OF MEDICINE,2017,55:20-25. |
| APA | Fredholm, Bertil B.,Yang, Jiangning,&Wang, Yingqing.(2017).Low, but not high, dose caffeine is a readily available probe for adenosine actions.MOLECULAR ASPECTS OF MEDICINE,55,20-25. |
| MLA | Fredholm, Bertil B.,et al."Low, but not high, dose caffeine is a readily available probe for adenosine actions".MOLECULAR ASPECTS OF MEDICINE 55(2017):20-25. |
入库方式： OAI收割
来源：上海药物研究所
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