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Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles

文献类型：期刊论文

作者Zhong, Tao1; He, Bin2,3; Cao, Hai-qiang2,3; Tan, Tao2,3; Hu, Hai-yan2,3; Li, Ya-ping2,3; Zhang, Zhi-wen2,3
刊名ACTA PHARMACOLOGICA SINICA
出版日期2017-06
卷号38期号:6页码:924-930
关键词micelles cabazitaxel cancer metastasis breast cancer 4T1 breast cancer cells
ISSN号1671-4083
DOI10.1038/aps.2017.36
文献子类Article
英文摘要Cancer metastasis is the primary cause of high mortality in breast cancer patients. In this study, we loaded an anti-cancer drug, cabazitaxel (CTX), into polymeric micelles (CTX-loaded polymeric micelles, PCMs), and explored their therapeutic efficacy in breast cancer metastasis. The characteristics of PCMs were investigated, and their anti-metastatic efficacy was assessed using in vitro and in vivo evaluations. PCMs had an average diameter of 50.13 +/- 11.96 nm with a CTX encapsulation efficiency of 97.02%+/- 0.97%. PCMs could be effectively internalized into metastatic 4T1 breast cancer cells in vitro. CTX (10 ng/mL) or an equivalent concentration in PCMs did not significantly affected the viability of 4T1 cells, but dramatically decreased the cell migration activities. In an orthotopic metastatic breast cancer model, intravenously administered PCMs could be efficiently delivered to the tumor sites, resulting in a 71.6% inhibition of tumor growth and a 93.5% reduction of lung metastases. Taken together, our results verify the anti-metastatic efficacy of PCMs, thus providing an encouraging strategy for treating breast cancer metastasis.
WOS关键词RESISTANT PROSTATE-CANCER ; TUMOR BLOOD-VESSELS ; LUNG METASTASIS ; DRUG-RESISTANCE ; THERAPEUTIC-EFFICACY ; MULTIDRUG-RESISTANCE ; IN-VITRO ; NANOPARTICLES ; DELIVERY ; CELLS
资助项目National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[81521005] ; Institutes for Drug Discovery and Development of CAS[CASIMM0120163005] ; Youth Innovation Promotion Association of CAS[00000000]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:5998012
WOS记录号WOS:000402526900017
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/272647]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Zhang, Zhi-wen
作者单位1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China;
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhong, Tao,He, Bin,Cao, Hai-qiang,et al. Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles[J]. ACTA PHARMACOLOGICA SINICA,2017,38(6):924-930.
APA Zhong, Tao.,He, Bin.,Cao, Hai-qiang.,Tan, Tao.,Hu, Hai-yan.,...&Zhang, Zhi-wen.(2017).Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles.ACTA PHARMACOLOGICA SINICA,38(6),924-930.
MLA Zhong, Tao,et al."Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles".ACTA PHARMACOLOGICA SINICA 38.6(2017):924-930.

入库方式： OAI收割

来源：上海药物研究所

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