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Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa

文献类型：期刊论文

作者Wu, Jie-Wei1,2,3; Tang, Chun-Ping1,2; Cai, Yao-Yao4; Ke, Chang-Qiang1,2; Lin, Li-Gen5; Yao, Sheng1,2; Ye, Yang1,2,6
刊名CHINESE CHEMICAL LETTERS
出版日期2017-05
卷号28期号:5页码:927-930
关键词Inula cappa Germacrane Sesquiterpene lactones Ineupatolide D Ineupatolide E
ISSN号1001-8417
DOI10.1016/j.cclet.2016.11.011
文献子类Article
英文摘要Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones, ineupatolides D and E (1 and 2), together with three known analogs. The structures of the new compounds were established by extensive analysis of 1D and 2D NMR spectra, as well as MS data. Their absolute configurations were determined by CD spectra. All compounds showed moderate inhibitory effects on A431, A549, BGC-823, HL-60, HT-29, and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 mu M. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词PHENOLIC GLYCOSIDES
资助项目National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds of China[81302657] ; National Natural Science Funds of China[81573305] ; National Natural Science Funds of China[81473112] ; Youth Innovation Promotion Association CAS[00000000] ; Ministry of Science and Technology[2010DFA30980] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] ; University of Macau[MYRG2014-00020-ICMS-QRCM] ; University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:6017533
WOS记录号WOS:000402444600001
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/272680]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Yao, Sheng; Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept NMR Technol Serv, Publ Tech Serv Ctr, Shanghai 201203, Peoples R China;
5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Jie-Wei,Tang, Chun-Ping,Cai, Yao-Yao,et al. Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa[J]. CHINESE CHEMICAL LETTERS,2017,28(5):927-930.
APA Wu, Jie-Wei.,Tang, Chun-Ping.,Cai, Yao-Yao.,Ke, Chang-Qiang.,Lin, Li-Gen.,...&Ye, Yang.(2017).Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa.CHINESE CHEMICAL LETTERS,28(5),927-930.
MLA Wu, Jie-Wei,et al."Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa".CHINESE CHEMICAL LETTERS 28.5(2017):927-930.

入库方式： OAI收割

来源：上海药物研究所

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