Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues
文献类型：期刊论文
| 作者 | Carbone, Marianna3; Ciavatta, M. Letizia3; Mathieu, Veronique4; Ingels, Aude4; Kiss, Robert4; Pascale, Paola3; Mono, Ernesto3; Ungur, Nicon1; Guo, Yue-Wei2 ; Gavagnin, Margherita3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2017-05 |
| 卷号 | 80期号:5页码:1339-1346 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b00941 |
| 文献子类 | Article |
| 英文摘要 | A new diacylguanidine, actinofide (1), has been isolated from the marine mollusk Actinocyclus papillatus. The structure, exhibiting a guanidine moiety acylated by two terpenoid acid units, has been established by spectroscopic methods and secured by synthesis. Following this, a series of structural analogues have been synthesized using the same procedure. All of the compounds have been evaluated in vitro for the growth inhibitory activity against a variety of cancer cell lines. |
| WOS关键词 | PTEROGYNE-NITENS ; CANCER-CELLS ; GUANIDINE ALKALOIDS ; MILLETTIA-LAURENTII ; MODEL ; DEATH ; APOPTOSIS ; PRODUCTS ; ACYLGUANIDINES ; TEMOZOLOMIDE |
| 资助项目 | MIUR-ITALY PRIN[2015MSCKCE_003] ; CNR (Italy)/ASM (Moldova) Joint Bilateral Project[00000000] ; NSFC[81520108028] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000402498300013 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272681]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei; Gavagnin, Margherita |
| 作者单位 | 1.Moldova Acad Sci, Inst Chem, Acad Str 3, MD-2028 Kishinev, Moldova; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.CNR, Ist Chim Biomol, Via Campi Flegrei 34, I-80078 Pozzuoli, Na, Italy; 4.Univ Libre Bruxelles, Fac Pharm, Lab Cancerol & Toxicol Expt, Campus Plaine,Blvd Triomphe, B-1050 Brussels, Belgium; |
| 推荐引用方式 GB/T 7714 | Carbone, Marianna,Ciavatta, M. Letizia,Mathieu, Veronique,et al. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(5):1339-1346. |
| APA | Carbone, Marianna.,Ciavatta, M. Letizia.,Mathieu, Veronique.,Ingels, Aude.,Kiss, Robert.,...&Gavagnin, Margherita.(2017).Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues.JOURNAL OF NATURAL PRODUCTS,80(5),1339-1346. |
| MLA | Carbone, Marianna,et al."Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues".JOURNAL OF NATURAL PRODUCTS 80.5(2017):1339-1346. |
入库方式： OAI收割
来源：上海药物研究所
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