Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity
文献类型：期刊论文
| 作者 | Niu, Biao1,5,6,7; Ke, Chang-Qiang5,6 ; Li, Bo-Han1,2; Li, Yuanyuan4; Yi, Yongji4; Luo, Yongwei4; Shuai, Lin1,2; Yao, Sheng5,6; Lin, Li-Gen3; Li, Jia1,2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2017-05 |
| 卷号 | 80期号:5页码:1428-1435 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b01086 |
| 文献子类 | Article |
| 英文摘要 | Seven new cucurbitane glucosides, 11-oxomogrosides III E and IV (1 and 2), 11-oxoisomogroside V (3), 7-oxomogrosides III E and W (4 and 5), and mogrosides VI A and VI B (6 and 7), were separated from the crude extract of Siraitia grosvenorii. The new structures were defined by analysis of their H-1 and C-13 NMR, 2D NMR, and HRESIMS data. Especially, the band-selective constant time HSQC and band-selective constant time HMBC techniques were recuited to elucidate the structures of the complex glucoside moieties. Using the PGC-la promoter driven luciferase reporter assay, the isolated compounds were examined for PGC-la promoter activity. |
| WOS关键词 | FRUCTUS MOMORDICAE ; GLYCOSIDES ; FRUITS ; CONSTITUENTS ; EXPRESSION ; METABOLISM ; DISEASE ; PGC-1 ; GENE |
| 资助项目 | National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds of China[81673327] ; Science and Technology Commission of Shanghai Municipality[15DZ2291600] ; Guangxi Science and Technology Department[14125008-2-29] ; State Key Laboratory of Drug Research[SIMM1501ZZ-03] ; University of Macau[MYRG2014-00020-ICMS-QRCM] ; University of Macau[MYRG2015-00153-ICMS-QRCM] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000402498300024 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272682]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, Chinese Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guoshoujing Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China 4.Guilin Layn Nat Ingredients Corp, Guilin 541199, Peoples R China; 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 6.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Niu, Biao,Ke, Chang-Qiang,Li, Bo-Han,et al. Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(5):1428-1435. |
| APA | Niu, Biao.,Ke, Chang-Qiang.,Li, Bo-Han.,Li, Yuanyuan.,Yi, Yongji.,...&Ye, Yang.(2017).Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity.JOURNAL OF NATURAL PRODUCTS,80(5),1428-1435. |
| MLA | Niu, Biao,et al."Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity".JOURNAL OF NATURAL PRODUCTS 80.5(2017):1428-1435. |
入库方式： OAI收割
来源：上海药物研究所
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