Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant
文献类型：期刊论文
| 作者 | Xu, Fuwang2; Xiao, Chengqian1; Lv, Xue1; Lei, Min1 ; Hu, Lihong1,2,3
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2017-03-29 |
| 卷号 | 58期号:13页码:1312-1315 |
| 关键词 | Xanthanolide Mogolide D Mogolide E Xanthatin Xanthium mogolium Kitag |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2017.02.044 |
| 文献子类 | Article |
| 英文摘要 | Two xanthanolide-type dimmers, namely Mogolide D (4) and Mogolide E (5) are isolated from the aerial parts of Xanthium mogolium Kitag plant collected from Heilongjiang province, China. The dimmers' relative structures are elucidated on the basis of HRESIMS, IR spectrum and NMR spectroscopy. The absolute configurations of them are assigned with ECD spectra. The biosynthetic pathway of the two dimmers is also proposed. Besides, Mogolide D (4) and Mogolide E (5) are tested against MDA-MB-231 breast cancer cell line with IC50 8.46 mu M and 19.20 mu M, respectively. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SESQUITERPENE LACTONES ; CARBAMATE DERIVATIVES ; CANCER-CELLS ; XANTHATIN ; INHIBITION ; DISCOVERY ; PATHWAY |
| 资助项目 | National Natural Science Foundation of China[81473110] ; Special Fund for Strategic Pilot Technology Chinese Academy of Sciences[XDA12040303] ; Shanghai Science & Technology Support Program[13431900401] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000397699400018 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272735]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lei, Min; Hu, Lihong |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 2.East China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China; 3.Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Sch Pharm, Jiangsu Key Lab Therapeut Mat Chinese Med, Nanjing, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Fuwang,Xiao, Chengqian,Lv, Xue,et al. Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant[J]. TETRAHEDRON LETTERS,2017,58(13):1312-1315. |
| APA | Xu, Fuwang,Xiao, Chengqian,Lv, Xue,Lei, Min,&Hu, Lihong.(2017).Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant.TETRAHEDRON LETTERS,58(13),1312-1315. |
| MLA | Xu, Fuwang,et al."Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant".TETRAHEDRON LETTERS 58.13(2017):1312-1315. |
入库方式： OAI收割
来源：上海药物研究所
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