Palladium-Catalyzed, Silver-Assisted Direct C-5-H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation
文献类型：期刊论文
| 作者 | Li, Shan2; Wan, Penghui3; Ai, Jing1 ; Sheng, Rong2; Hu, Yongzhou2; Hu, Youhong3
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2017-03-06 |
| 卷号 | 359期号:5页码:772-778 |
| 关键词 | C-H activation concerted metalation-deprotonation (CMD) pathway 3,5-diaryl-1,2,4-oxadiazoles 1,2,4-oxadiazoles |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201600913 |
| 文献子类 | Article |
| 英文摘要 | A direct C-5-H arylation of 3-substituted 1,2,4-oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5-diaryl-1,2,4-oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. |
| WOS关键词 | ARYL BROMIDES ; AMIDOXIMES ; ACTIVATION ; 3,5-DISUBSTITUTED-1,2,4-OXADIAZOLES ; CHLORIDES ; ARENES ; C-2 |
| 资助项目 | Science and Technology Department of Zhejiang Province[2014C33181] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000396631700002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272748]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Sheng, Rong; Hu, Youhong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, 555 ZuChongZhi Rd, Shanghai 201203, Peoples R China 2.Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 ZuChongZhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Shan,Wan, Penghui,Ai, Jing,et al. Palladium-Catalyzed, Silver-Assisted Direct C-5-H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation[J]. ADVANCED SYNTHESIS & CATALYSIS,2017,359(5):772-778. |
| APA | Li, Shan,Wan, Penghui,Ai, Jing,Sheng, Rong,Hu, Yongzhou,&Hu, Youhong.(2017).Palladium-Catalyzed, Silver-Assisted Direct C-5-H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation.ADVANCED SYNTHESIS & CATALYSIS,359(5),772-778. |
| MLA | Li, Shan,et al."Palladium-Catalyzed, Silver-Assisted Direct C-5-H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation".ADVANCED SYNTHESIS & CATALYSIS 359.5(2017):772-778. |
入库方式： OAI收割
来源：上海药物研究所
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