Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells
文献类型：期刊论文
| 作者 | Luo, Lian-Xiang2; Fan, Xing-Xing2; Li, Ying2; Peng, Xia1; Ji, Yin-Chun1; Hsiao, Wendy Wen-Luan2; Liu, Liang2; Leung, Elaine Lai-Han2; Yao, Xiao-Jun2 |
| 刊名 | MEDCHEMCOMM
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 8期号:3页码:621-624 |
| ISSN号 | 2040-2503 |
| DOI | 10.1039/c6md00643d |
| 文献子类 | Article |
| 英文摘要 | Mitoxantrone, an FDA-approved drug for multiple sclerosis and hormone refractory prostate cancer, is identified as a potent inhibitor of ROS1 fusion protein by in silico screening in non-small cell lung cancer cells. Mitoxantrone can suppress the phosphorylation of ROS1 and subsequently inhibit its downstream signaling pathway and thus induce cell apoptosis. |
| WOS关键词 | POTENT INHIBITOR ; OLD DRUGS ; TARGETS ; CRIZOTINIB ; DISCOVERY ; TRICKS |
| 资助项目 | Macao Science and Technology Development Fund[082/2013/A3] ; Macao Science and Technology Development Fund[086/2015/A3] ; Macao Science and Technology Development Fund[005/2014/AMJ] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000398533700014 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272749]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Liang; Leung, Elaine Lai-Han; Yao, Xiao-Jun |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau Inst Appl Res Med & Hlth, Taipa, Macau Sar, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Luo, Lian-Xiang,Fan, Xing-Xing,Li, Ying,et al. Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells[J]. MEDCHEMCOMM,2017,8(3):621-624. |
| APA | Luo, Lian-Xiang.,Fan, Xing-Xing.,Li, Ying.,Peng, Xia.,Ji, Yin-Chun.,...&Yao, Xiao-Jun.(2017).Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells.MEDCHEMCOMM,8(3),621-624. |
| MLA | Luo, Lian-Xiang,et al."Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells".MEDCHEMCOMM 8.3(2017):621-624. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。