Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives
文献类型：期刊论文
| 作者 | Xiao, Chengqian2; Tian, Yunan1; Lei, Min2 ; Chen, Fanglei2; Gan, Xianwen2; Yao, Xingang1; Shen, Xu1; Chen, Jing1; Hu, Lihong2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 27期号:5页码:1316-1318 |
| 关键词 | Vindoline Natural product Glucose-stimulate insulin secretion (GSIS) Structure-activity relationships (SARs) |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2016.09.064 |
| 文献子类 | Article |
| 英文摘要 | It is demonstrated that natural product vindoline can enhance the glucose-stimulated insulin secretion (GSIS) in MIN6 cells with the EC50 value of 50.2 mu M. In order to improve the activities, a series of vindoline derivatives are synthesized and evaluated in MIN6 cells. Compounds 4, 8, 17 and 24 show about 4.5 times more effective stimulation insulin secretion ability (EC50: 10.4, 14.2, 11.0 and 12.7 mu M, respectively) than vindoline. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | VINFLUNINE ; RESISTANCE |
| 资助项目 | National Natural Science Foundation of China[81273397] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000395967900039 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272751]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Lei, Min; Chen, Jing; Hu, Lihong |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Univ Chinese Acad Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Univ Chinese Acad Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xiao, Chengqian,Tian, Yunan,Lei, Min,et al. Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(5):1316-1318. |
| APA | Xiao, Chengqian.,Tian, Yunan.,Lei, Min.,Chen, Fanglei.,Gan, Xianwen.,...&Hu, Lihong.(2017).Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(5),1316-1318. |
| MLA | Xiao, Chengqian,et al."Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.5(2017):1316-1318. |
入库方式： OAI收割
来源：上海药物研究所
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