Periplocoside A ameliorated type II collagen-induced arthritis in mice via regulation of the balance of Th17/Treg cells
文献类型：期刊论文
| 作者 | Yang, Yang2; Hu, Xudong2; Cheng, Lei3; Tang, Wei3 ; Zhao, Weimin1; Yang, Yifu2; Zuo, Jianping2,3
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| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
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| 出版日期 | 2017-03 |
| 卷号 | 44页码:43-52 |
| 关键词 | Periplocoside A Collagen-induced arthritis Th17 cell Regulatory T cell Rheumatoid arthritis Immunosuppression |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2016.12.013 |
| 文献子类 | Article |
| 英文摘要 | Periplocoside A (PSA) has been extracted from the Chinese herbal medicine Periploca sepium Bge to treat rheumatoid arthritis (RA) via immune regulation. We previously found that PSA exhibits immunosuppressive activity both in vitro and in vivo. Balanced regulation of helper T 17 (Th17)/regulatory T (Treg) cells is the current therapeutic direction for the treatment of RA. The present study investigated the mechanism of PSA in treating collagen-induced arthritis (CIA). The therapeutic effects and potential pharmacological mechanisms of PSA were specifically clarified by examining its effects on CIA in DBA/1 mice. PSA administration significantly relieved the severity of the arthritis, and preventive administration of PSA reduced the incidence of arthritis in the mice with CIA and relieved joint damage in terms of morphology. PSA was also able to reduce the levels of anti-collagen II (CII) antibodies and pro-inflammatory cytokines in the serum. As a result, the proportion of Th17 cells decreased, and the proportion of Treg cells increased. A follow-up study of the ex vivo immunological reactions induced by a specific antigen found that PSA suppressed lymphocyte proliferation, inhibited the differentiation and reactivity of Th17 cells, and promoted the proportion of Treg cells among helper T cells. PSA also exhibited pharmacological effect in regulating the balance between Th17 and Treg cells in CIA through relevant signalling pathways. Thus, PSA played a specific role in CIA treatment. In particular, our results suggest that the therapeutic effects of PSA on RA are partially realized via the regulation of the balance of Th17/Freg cells. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS关键词 | AUTOIMMUNE ARTHRITIS ; RHEUMATOID-ARTHRITIS ; T-CELLS ; SEPIUM BGE ; IN-VIVO ; TH17 ; GAMMA ; SUPPRESSION ; INTERLEUKIN-17 ; INFLAMMATION |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2014ZX09101002] ; Shanghai Municipal Commission of Health and Family Planning[201224y015] ; Shanghai Municipal Education Commission[2012JW20] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000394918700006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272753]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yifu; Zuo, Jianping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Beijing, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Lab Immunol & Virol, Shanghai, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Yang,Hu, Xudong,Cheng, Lei,et al. Periplocoside A ameliorated type II collagen-induced arthritis in mice via regulation of the balance of Th17/Treg cells[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2017,44:43-52. |
| APA | Yang, Yang.,Hu, Xudong.,Cheng, Lei.,Tang, Wei.,Zhao, Weimin.,...&Zuo, Jianping.(2017).Periplocoside A ameliorated type II collagen-induced arthritis in mice via regulation of the balance of Th17/Treg cells.INTERNATIONAL IMMUNOPHARMACOLOGY,44,43-52. |
| MLA | Yang, Yang,et al."Periplocoside A ameliorated type II collagen-induced arthritis in mice via regulation of the balance of Th17/Treg cells".INTERNATIONAL IMMUNOPHARMACOLOGY 44(2017):43-52. |
入库方式： OAI收割
来源：上海药物研究所
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