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Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada

文献类型：期刊论文

作者Li, Xiao-Lu2,3; Kurtan, Tibor1; Hu, Jun -Chi2,3; Mandi, Attila1; Li, Jia2; Li, Xu-Wen2; Guo, Yue-Wei2
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2017-03-01
卷号65期号:8页码:1550-1555
关键词sesquiterpenoid laurane red alga axial chirality PTP1B
ISSN号0021-8561
DOI10.1021/acsjafc.6b05238
文献子类Article
英文摘要Three novel heterodimeric laurane-type sesquiterpenoids, laurokamurols A-C (1-3), along with eight known related monomeric ones (4-11) were isolated from the East China Sea red alga Laurencia okamurai Yamada. The absolute configurations of the new bis-sesquitepenoids, especially their axial chirality, were determined by extensive spectroscopic analyses and TDDFT-ECD method. All of the new compounds showed promising PTP1B inhibitory activities with IC50 values comparable to the positive control, indicating them as potential food additives or pharmaceutical drug leads toward obesity or diabetes.
WOS关键词LAURANE SESQUITERPENE ; ORIGIN CHEMISTRY ; MARINE-ALGAE ; OBTUSA ; MICROCLADIA ; DERIVATIVES ; APLYSINOL ; PRODUCTS
资助项目Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41676073] ; Natural Science Foundation of China[81603022] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; Institutes for Drug Discovery and Development[00000000] ; Chinese Academy of Sciences[CASIIVIM0120152039] ; SKLDR/SIMM Projects[SIMM 1501ZZ-03] ; Youth Innovation Promotion Association" from the Chinese Academy of Sciences[2016258] ; "Young Talent Supporting Project" from the China Association for Science and Technology[2016QNRC001] ; Shanghai "Pujiang Program"[16PJ1410600] ; EU[00000000] ; European Regional Development Fund[GINOP-2.3.2-15-2016-00008]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000395493500011
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/272762]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Univ Debrecen, Dept Organ Chem, Egyetemter 1,POB 400, H-4002 Debrecen, Hungary
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Xiao-Lu,Kurtan, Tibor,Hu, Jun -Chi,et al. Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(8):1550-1555.
APA Li, Xiao-Lu.,Kurtan, Tibor.,Hu, Jun -Chi.,Mandi, Attila.,Li, Jia.,...&Guo, Yue-Wei.(2017).Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,65(8),1550-1555.
MLA Li, Xiao-Lu,et al."Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.8(2017):1550-1555.

入库方式： OAI收割

来源：上海药物研究所

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