Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity
文献类型：期刊论文
| 作者 | Sun, Pan5; Jiang, Chang-Sheng5; Zhang, Yi5; Liu, Ai -Hong1; Liang, Tong -Jun3; Li, Jia2 ; Guo, Yue-Wei2; Jiang, Jian-Mei4; Mao, Shui-Chun5; Wang, Bin5
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| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
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| 出版日期 | 2017-03 |
| 卷号 | 65期号:3页码:295-299 |
| 关键词 | Aglaia abbreviata prenylated bibenzyl aglaiabbrevin protein tyrosine phosphatase-1B inhibitor potential lead compound |
| ISSN号 | 0009-2363 |
| 文献子类 | Article |
| 英文摘要 | Four new prenylated bibenzyls, named aglaiabbrevins A-D (2, 4-6), were isolated from the leaves of Aglaia abbreviata, along with two known related analogues, 3,5-dihydroxy-2-[3,7-dimethyl-2(E),6-octadienyl] bibenzyl (7) and 3,5-dihydroxy-2-(3-methyl-2-butenyl)bibenzyl (8). The structures of the new compounds were elucidated on the basis of extensive spectroscopic experiments, mainly one and two dimensional (1D and 2D)-NMR, and the absolute configuration of 5 was determined by the measurement of specific rotation. The isolated compounds were evaluated for their protein tyrosine phosphatase-1B (PTP1B) inhibitory activity. The results showed that compounds 5-7 exhibited more potent PTP1B inhibitory effects with IC50 values of 2.58 +/- 0.52, 2.44 +/- 0.35, and 2.23 +/- 0.14 mu m, respectively, than the positive control oleanolic acid (IC50=2.74 +/- 0.20 mu m). On the basis of the data obtained, these bibenzyls with the longer C-2 prenyl groups may be considered as potential lead compounds for the development of new anti-obesity and anti-diabetic agents. Also, the PTP1B inhibitory effects for prenylated bibenzyls are being reported for the first time. |
| WOS关键词 | ALGA CAULERPA-RACEMOSA ; CHEMOSYSTEMATICS ; DITERPENOIDS ; CONSTITUENTS ; BRYOPHYTES |
| 资助项目 | National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; National Natural Science Foundation of China[21362024] ; Young Scientists Training Program of Jiangxi Province[20133BCB23004] ; Natural Science Foundation of Jiangxi Province, China[20151BAB205082] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; State Key Laboratory of Drug Research-SIMM[SIMM1601KF-10] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000395364000011 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272763]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 药物安全性评价中心 |
| 通讯作者 | Mao, Shui-Chun; Wang, Bin |
| 作者单位 | 1.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Jiangxi Prov & Chinese Acad Sci, Lushan Bot Garden, Lushan 332900, Peoples R China; 4.Nanchang Univ, Sch Med, Nanchang 330006, Jiangxi, Peoples R China 5.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Sun, Pan,Jiang, Chang-Sheng,Zhang, Yi,et al. Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2017,65(3):295-299. |
| APA | Sun, Pan.,Jiang, Chang-Sheng.,Zhang, Yi.,Liu, Ai -Hong.,Liang, Tong -Jun.,...&Wang, Bin.(2017).Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity.CHEMICAL & PHARMACEUTICAL BULLETIN,65(3),295-299. |
| MLA | Sun, Pan,et al."Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity".CHEMICAL & PHARMACEUTICAL BULLETIN 65.3(2017):295-299. |
入库方式： OAI收割
来源：上海药物研究所
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