Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity
文献类型：期刊论文
| 作者 | Lin, Li-Gen1; Leung, Henry Pak-Ho2; Zhu, Jian-Yu3; Tang, Chun-Ping1 ; Ke, Chang-Qiang1; Rudd, John A.2; Lin, Ge2; Ye, Yang1
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2008-10-27 |
| 卷号 | 64期号:44页码:10155-10161 |
| 关键词 | Stemona tuberosa Croomine-type alkaloids Tuberostemonine-type alkaloids Antitussive Croomine |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2008.08.046 |
| 文献子类 | Article |
| 英文摘要 | Three new croomine-type Stemona alkaloids, tuberocrooline (1), 10-hydroxycroomine (2), and dehydrocroomine (3), and four new tuberostemonine-type alkaloids, tuberostemoline (4), triclehydrotuberostemonine (5), 9 alpha-bisdehydrotuberostemonine (6), and 9 alpha-bisdehydrottiberostemonine A (7), along with ten known constituents, were isolated from the roots of Stemona tuberosa collected from Yunnan province. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectra and other spectroscopic studies. The antitussive activity of the major alkaloids was tested using the Citric acid-induced guinea pig cough model. Croomine (8) exhibited a dose-dependent inhibition of coughing with an ID50 value of 0.18 mmol/kg. (c) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MODELS ; COUGH |
| 资助项目 | Ministry of Science and Technology[2004CB518902] ; Ministry of Science and Technology[2007DFC31030] ; Shanghai Municipality[07D219728] ; Shanghai Municipal Education Commission[060Z013] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000260290500005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272776]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lin, Ge |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Univ Hong Kong, Dept Pharmacol, Fac Med, Shatin, Hong Kong, Peoples R China; 3.Shanghai Inst Technol, Shanghai 200235, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Li-Gen,Leung, Henry Pak-Ho,Zhu, Jian-Yu,et al. Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity[J]. TETRAHEDRON,2008,64(44):10155-10161. |
| APA | Lin, Li-Gen.,Leung, Henry Pak-Ho.,Zhu, Jian-Yu.,Tang, Chun-Ping.,Ke, Chang-Qiang.,...&Ye, Yang.(2008).Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity.TETRAHEDRON,64(44),10155-10161. |
| MLA | Lin, Li-Gen,et al."Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity".TETRAHEDRON 64.44(2008):10155-10161. |
入库方式： OAI收割
来源：上海药物研究所
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