Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia
文献类型：期刊论文
| 作者 | Zhang, Hai Yan; Zheng, Chun Yan; Yan, Han; Wang, Zhi Fei; Tang, Li Li; Gao, Xin; Tang, Xi Can |
| 刊名 | CHEMICO-BIOLOGICAL INTERACTIONS
 |
| 出版日期 | 2008-09-25 |
| 卷号 | 175期号:1-3页码:396-402 |
| 关键词 | Alzheimer's disease Huperzine A Acetylcholinesterase inhibitor beta-Amyloid Mitochondrial dysfunction Inflammation |
| ISSN号 | 0009-2797 |
| DOI | 10.1016/j.cbi.2009.04.049 |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | Huperzine A (HupA), a novel Lycopodium alkaloid isolated from Chinese folk medicine Huperzia serrata (Qian Ceng Ta), is a potent, selective and well-tolerated inhibitor of acetylcholinesterase (AChE). It has been proven to significantly improve the learning and memory impairment in Alzheimer's disease (AD) and vascular dementia (VaD) patients in China. interestingly, Our recent data indicate that HupA also possesses other protective functions. This paper will give an overview on the protective effects of HupA,which includes regulating beta-amyloid precursor Protein (APP) metabolism, Protecting against A beta-mediated oxidative stress, apoptosis and mitochondrial dysfunction, as well as anti-inflammation. The multiple neuroprotective effects of HupA might yield additional beneficial effects in AD and VaD therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | AMYLOID-BETA-PEPTIDE ; RAT CORTICAL-NEURONS ; MUSCARINIC ACETYLCHOLINE-RECEPTORS ; PROTEIN-KINASE-C ; OXYGEN-GLUCOSE DEPRIVATION ; SWEDISH MUTANT-CELLS ; NERVE GROWTH-FACTOR ; PRECURSOR PROTEIN ; CHOLINESTERASE-INHIBITORS ; MITOCHONDRIAL DYSFUNCTION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000260110500075 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272804]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Tang, Xi Can |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hai Yan,Zheng, Chun Yan,Yan, Han,et al. Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2008,175(1-3):396-402. |
| APA | Zhang, Hai Yan.,Zheng, Chun Yan.,Yan, Han.,Wang, Zhi Fei.,Tang, Li Li.,...&Tang, Xi Can.(2008).Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.CHEMICO-BIOLOGICAL INTERACTIONS,175(1-3),396-402. |
| MLA | Zhang, Hai Yan,et al."Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia".CHEMICO-BIOLOGICAL INTERACTIONS 175.1-3(2008):396-402. |
入库方式： OAI收割
来源：上海药物研究所
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