DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks
文献类型：期刊论文
| 作者 | Xiong, Bing1 ; Liu, Ke1; Wu, Jie1; Burk, David L.2; Jiang, Hualiang1; Shen, Jingkang1
|
| 刊名 | BIOINFORMATICS
 |
| 出版日期 | 2008-09-15 |
| 卷号 | 24期号:18页码:2117-2118 |
| ISSN号 | 1367-4803 |
| DOI | 10.1093/bioinformatics/btn389 |
| 文献子类 | Article |
| 英文摘要 | DrugViz is a Cytoscape plugin that is designed to visualize and analyze small molecules within the framework of the interactome. DrugViz can import drugtarget network information in an extended SIF file format to Cytoscape and display the two-dimensional (2D) structures of small molecule nodes in a unified visualization environment. It also can identify small molecule nodes by means of three different 2D structure searching methods, namely isomorphism, substructure and fingerprint-based similarity searches. After selections, users can furthermore conduct a two-side clustering analysis on drugs and targets, which allows for a detailed analysis of the active compounds in the network, and elucidate relationships between these drugs and targets. DrugViz represents a new tool for the analysis of data from chemogenomics, metabolomics and systems biology. |
| 资助项目 | National Natural Science Foundation of China[30600784] ; Science and Technology Commission Of Shanghai Municipality[06zr14101] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics |
| 语种 | 英语 |
| WOS记录号 | WOS:000258959600028 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272808]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Shen, Jingkang |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.McGill Univ, Dept Biochem, Montreal, PQ H3A 1A4, Canada |
| 推荐引用方式 GB/T 7714 | Xiong, Bing,Liu, Ke,Wu, Jie,et al. DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks[J]. BIOINFORMATICS,2008,24(18):2117-2118. |
| APA | Xiong, Bing,Liu, Ke,Wu, Jie,Burk, David L.,Jiang, Hualiang,&Shen, Jingkang.(2008).DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks.BIOINFORMATICS,24(18),2117-2118. |
| MLA | Xiong, Bing,et al."DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks".BIOINFORMATICS 24.18(2008):2117-2118. |
入库方式： OAI收割
来源：上海药物研究所
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