Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions
文献类型：期刊论文
| 作者 | Wan, Jin1; Zhu, Yi-Na1; Feng, Jia-Quan1; Chen, Hai-Jun1; Zhang, Ru-Jun1; Ni, Jia1; Chen, Zhen-Hua1; Hou, Li-Fei1; Liu, Quan-Fang1; Zhang, Jing1 |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2008-09 |
| 卷号 | 8期号:9页码:1248-1256 |
| 关键词 | P. sepium bge PSA ConA-induced hepatitis NKT cell |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2008.05.001 |
| 文献子类 | Article |
| 英文摘要 | Periploca sepium Bge, a traditional Chinese herb medicine, is widely used for treating rheumatoid arthritis in china. Periplocoside A (PSA), a pregnane glycoside, is a new nature product compound isolated from P. sepium Bge. We examined the protective effects of PSA, on concanavaline A (ConA)-induced hepatitis. Pretreatment with PSA dramatically ameliorated ConA-induced liver injury, which was characterized by reducing serum alanine transaminase (ALT), pathogenic cytokines of interteukin (IL)-4 and interferon (IFN)-gamma levels, impeding the liver necrosis, and thus elevating the survival rate. In vitro, PSA inhibited IL-4 and IFN-gamma productions of alpha-galactosylceramide (alpha-GalCer) or anti-CD3-activated Natural killer T (NKT) cells. Enzyme Linked Immunosorbent Assay (ELISA) and Reverse Transcription Polymerase Chain Reaction (RTPCR) assays revealed PSA suppressed IL-4 transcription and IFN-gamma translation. In conclusion, PSA had significantly preventative effect on ConA-induced hepatitis, which was closely associated with inhibition of NKT-derived inflammatory cytokine productions. These findings suggested that PSA has the therapeutic potential for treatment of human autoimmune-related hepatitis. (c) 2008 Elsevier B.V. All rights reserved. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; CELL-MEDIATED HEPATITIS ; INDUCED LIVER-INJURY ; KILLER T-CELLS ; INTERFERON-GAMMA ; AUTOIMMUNE HEPATITIS ; IN-VIVO ; ACTIVATION ; LYMPHOCYTES ; CD4(+) |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000258050400012 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272821]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Zhao, Wei-Ming |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Jin,Zhu, Yi-Na,Feng, Jia-Quan,et al. Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2008,8(9):1248-1256. |
| APA | Wan, Jin.,Zhu, Yi-Na.,Feng, Jia-Quan.,Chen, Hai-Jun.,Zhang, Ru-Jun.,...&Zuo, Jian-Ping.(2008).Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions.INTERNATIONAL IMMUNOPHARMACOLOGY,8(9),1248-1256. |
| MLA | Wan, Jin,et al."Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions".INTERNATIONAL IMMUNOPHARMACOLOGY 8.9(2008):1248-1256. |
入库方式： OAI收割
来源：上海药物研究所
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