Copper-catalyzed intramolecular cyclization to N-substituted 1,3-dihydrobenzimidazol-2-ones
文献类型：期刊论文
| 作者 | Li, Zhaoguang1,2; Sun, Hongbin2; Jiang, Hualiang3 ; Liu, Hong1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2008-08-07 |
| 卷号 | 10期号:15页码:3263-3266 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol8011106 |
| 文献子类 | Article |
| 英文摘要 | An efficient and convenient method was developed for preparing N-substituted 1,3-dihydrobenzimidazol-2-ones from N'-substituted N-(2-halophenyl)ureas via a Cul/DBU-catalyzed cyclization in DMSO under microwave heating. High yields were obtained and a variety of functional groups were tolerated under these conditions, including N'-aryl, alkyl, heterocyclic, various N-(substituted 2-halophenyl) and N-(2-iodopyridyl)ureas. |
| WOS关键词 | NITROGEN-HETEROCYCLES ; C-N ; RECEPTOR ANTAGONISTS ; BOND FORMATION ; ARYL HALIDES ; ARYLATION ; INHIBITORS ; NUCLEOPHILES ; BENZOXAZOLES ; INDOLES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000257955100024 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272841]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res,Drug Discovery & Design Ct, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Coll Pharm China, Ctr Drug Discovery, Nanjing 210009, Peoples R China; 3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhaoguang,Sun, Hongbin,Jiang, Hualiang,et al. Copper-catalyzed intramolecular cyclization to N-substituted 1,3-dihydrobenzimidazol-2-ones[J]. ORGANIC LETTERS,2008,10(15):3263-3266. |
| APA | Li, Zhaoguang,Sun, Hongbin,Jiang, Hualiang,&Liu, Hong.(2008).Copper-catalyzed intramolecular cyclization to N-substituted 1,3-dihydrobenzimidazol-2-ones.ORGANIC LETTERS,10(15),3263-3266. |
| MLA | Li, Zhaoguang,et al."Copper-catalyzed intramolecular cyclization to N-substituted 1,3-dihydrobenzimidazol-2-ones".ORGANIC LETTERS 10.15(2008):3263-3266. |
入库方式： OAI收割
来源：上海药物研究所
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