Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia
文献类型：期刊论文
| 作者 | Wang, Zhi-Fei; Wang, Juan; Zhang, Hai-Yan ; Tang, Xi-Can
|
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2008-08 |
| 卷号 | 106期号:4页码:1594-1603 |
| 关键词 | acetylcholinesterase inhibitor cholinergic antiinflammatory pathway huperzine A middle cerebral artery occlusion nicotinic acetylcholine receptor |
| ISSN号 | 0022-3042 |
| DOI | 10.1111/j.1471-4159.2008.05504.x |
| 文献子类 | Article |
| 英文摘要 | Huperzine A, a reversible and selective acetylcholinesterase (AChE) inhibitor, has been reported to display neuroprotective properties. The present study investigated the protective effects of huperzine A in a rat model of transient focal cerebral ischemia created by middle cerebral artery occlusion (MCAO). Huperzine A (0.1 mg/kg), administrated intraperitoneally at the onset of occlusion and 6 h later, markedly restored regional cerebral blood flow, reduced infarct size, and decreased neurological deficit score at 24 h after reperfusion. Along with inhibiting AChE activity, huperzine A inhibited nuclear translocation of transcription factor nuclear factor-kappa B, decreased overexpression of proinflammatory factors in both ipsilateral cortex and striatum, and suppressed activation of glial cells in the ischemic penumbra. Neurological deficit and glial cells activation were also reduced by daily administration of huperzine A for 14 days. Mecamylamine, a nicotinic acetylcholine receptor (nAChR) antagonist, totally abolished the inhibitory effects of huperzine A on ischemia-induced glial cells activation. Meanwhile, mecamylamine partially reversed the infarct size-reducing effects of huperzine A. In conclusion, our results demonstrate that huperzine A exhibits neuroprotective effects against transient focal cerebral ischemia-induced brain injury and suggest that the protection mechanism may involve a cholinergic anti-inflammatory pathway, in which nAChR plays an essential role. |
| WOS关键词 | ATTENUATES COGNITIVE DEFICITS ; NF-KAPPA-B ; ARTERY OCCLUSION ; ACETYLCHOLINESTERASE INHIBITORS ; BLOOD-FLOW ; CHOLINESTERASE INHIBITOR ; VASCULAR DEMENTIA ; INDUCED INJURY ; UP-REGULATION ; BRAIN-DAMAGE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000258170400012 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272856]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 院士及顾问专家 |
| 通讯作者 | Zhang, Hai-Yan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhi-Fei,Wang, Juan,Zhang, Hai-Yan,et al. Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia[J]. JOURNAL OF NEUROCHEMISTRY,2008,106(4):1594-1603. |
| APA | Wang, Zhi-Fei,Wang, Juan,Zhang, Hai-Yan,&Tang, Xi-Can.(2008).Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.JOURNAL OF NEUROCHEMISTRY,106(4),1594-1603. |
| MLA | Wang, Zhi-Fei,et al."Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia".JOURNAL OF NEUROCHEMISTRY 106.4(2008):1594-1603. |
入库方式： OAI收割
来源：上海药物研究所
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